西南医科大学学报2024，Vol.47Issue(4)：364-368,5.DOI:10.3969/j.issn.2096-3351.2024.04.017
PPARγ在免疫和造血系统中的研究进展
Research progress of PPARγ in the immune and hematopoietic systems
摘要
Abstract
Peroxisome proliferator-activated receptor γ(PPARγ)is a member of the type Ⅱ nuclear hormone receptor superfam-ily,which can regulate the transcription and expression of many genes.Since its discovery in the early 1990s,PPARγ has been known for its key roles in adipocyte differentiation and glucose metabolism.In recent years,some new discoveries have been made about PPARγ's involvement in the immune system and hematopoietic system,providing new insights into the pathogenesis of related dis-eases.This article reviewed the structure,subtype,and function of PPARγ and its research progress in the immune and hematopoietic systems.The new evidence indicates PPARγ is essential for the differentiation and function of various immune system cell types,such as dendritic cells,macrophages,and lymphocytes.Besides,PPARγ regulates hematopoiesis by affecting the proliferation and differentia-tion of hematopoietic stem cells and mesenchymal stem cells.Dysregulation of PPARγ signaling may be associated with the develop-ment of hematopoietic and immune system diseases.Further understanding the molecular mechanisms of PPARγ in the immune and he-matopoietic systems may provide theoretical reference for the targeted treatment of related diseases.关键词
过氧化物酶体增殖物激活受体γ/造血系统/免疫系统/间充质干细胞Key words
PPARγ/Hematopoietic system/Immune system/Mesenchymal stem cells分类
临床医学引用本文复制引用
熊彬,王雪梅..PPARγ在免疫和造血系统中的研究进展[J].西南医科大学学报,2024,47(4):364-368,5.基金项目
四川省科技厅科技计划项目(2020YJ0339) （2020YJ0339）
泸州市科技局科技计划重点研发项目(2019-SYF-36) （2019-SYF-36）
