国际眼科杂志2024，Vol.24Issue(8)：1223-1228,6.DOI:10.3980/j.issn.1672-5123.2024.8.08
褪黑素调节血管生成在眼底疾病中的研究进展
Research progress of melatonin in regulating angiogenesis in fundus diseases
摘要
Abstract
Angiogenesis is a key step involving physiological and pathological processes,and pro/antiangiogenic factors are involved in angiogenesis throughout.Melatonin is a product synthesized by the pineal gland of the human brain and acts in various systems of the body.This article briefly describes the wide range of biological roles and physiological functions of melatonin,and summarizes that melatonin regulates pro-/anti-angiogenic factors(e.g.,vascular endothelial growth factor/matrix metalloproteinase)under different conditions and is involved in angiogenesis in fundus diseases(e.g.,age-related macular degeneration,diabetic retinopathy,and central serous choroioretinopathy);in addition,it also summarizes that melatonin regulates various cytokines,inflammatory factors and signaling pathways to produce anti-inflammatory,antioxidant and immune responses in fundus diseases,and thus obtaining the application and potential treatment of melatonin in fundus vascular diseases,with a view to providing new ideas and therapeutic targets for the treatment of fundus diseases.关键词
年龄相关性黄斑变性/糖尿病视网膜病变/中心性浆液性脉络膜视网膜病变/褪黑素/血管生成Key words
age-related macular degeneration/diabetic retinopathy/central serous chorioretinopathy/melatonin/angiogenesis引用本文复制引用
杨凌齐,李鉴峰,吕洋..褪黑素调节血管生成在眼底疾病中的研究进展[J].国际眼科杂志,2024,24(8):1223-1228,6.基金项目
国家自然科学基金资助项目(No.82000926) （No.82000926）
甘肃省卫生健康行业科研项目(No.GSWSKY2022-05) （No.GSWSKY2022-05）
中国人民解放军联勤保障部队第九四○医院基金资助项目(No.2021yxky033,2023YXKY033) （No.2021yxky033,2023YXKY033）
甘肃省中医药大学导师专项(No.2023YXKY011) National Natural Science Foundation of China(No.82000926) （No.2023YXKY011）
Gansu Province Health Commission Fund Project(No.GSWSKY2022-05) （No.GSWSKY2022-05）
Scientific Foundation Program of the 940th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army(No.2021yxky033,2023YXKY033) （No.2021yxky033,2023YXKY033）
Tutor Foundation Project of Gansu University of Chinese Medicine(No.2023YXKY011) （No.2023YXKY011）
