器官移植2024，Vol.15Issue(4)：563-569,7.DOI:10.3969/j.issn.1674-7445.2024040
成人再次肝移植研究进展
Research progress in adult liver retransplantation
摘要
Abstract
Liver retransplantation is the final option for graft failure after liver transplantation.The interval between the first and second liver transplantation will directly affect surgical indications,technical diffiiculties and treatment outcomes of adult liver retransplantation.Previous studies have shown that the overall survival of liver allografts and recipients after liver retransplantation is significantly lower than that after the first liver transplantation.However,with comprehensive progress in organ preservation methods,anesthesia management concepts,intensive care strategies,surgical techniques and new immunosuppressive drugs,clinical efficacy of adult liver retransplantation has been significantly improved.In this article,the changes of indications,timing of operation,long-term effiicacy and its influencing factors,technical difficulties,selection of immunosuppressive regimens and the implementation of living donor liver retransplantation were reviewed,and the achievements,challenges and potential solutions of adult liver retransplantation were summarized,aiming to provide reference for enhancing clinical efficacy of adult liver retransplantation.关键词
再次肝移植/移植肝衰竭/活体肝移植/免疫抑制/免疫诱导/排斥反应/手术并发症/疾病复发Key words
Liver retransplantation/Liver graft failure/Living donor liver transplantation/Immunosuppression/Immune induction/Rejection/Surgical complication/Disease recurrence分类
医药卫生引用本文复制引用
吴若林,赵红川,耿小平..成人再次肝移植研究进展[J].器官移植,2024,15(4):563-569,7.基金项目
安徽省自然科学基金青年基金项目(2008085QH361) （2008085QH361）
