器官移植2024，Vol.15Issue(4)：575-580,6.DOI:10.3969/j.issn.1674-7445.2024039
耐受性树突状细胞在肝移植免疫耐受中的作用研究进展
Research progress on the role of tolerogenic dendritic cells in immune tolerance of liver transplantation
摘要
Abstract
Rejection after liver transplantation severely affects the survival of recipients.Long-term use of immunosuppressants is an important approach to prevent rejection,whereas it may cause toxic effects and increase the risk of adverse events such as systemic infection and tumor recurrence,etc.Therefore,before successful liver transplantation,how to induce individual immune tolerance of recipients and achieve complete or early withdrawal of postoperative immunosuppressants remains to be investigated by practitioners of organ transplantation.In recent years,certain progresses have been made in the mechanism of immune tolerance induced by tolerogenic dendritic cells in liver transplantation,and preliminary outcomes have been obtained in clinical trials.In this article,basic research and clinical application progress in the characteristics of tolerogenic dendritic cells,the mechanism underlying participating in liver immune microenvironment remodeling,and inducing immune tolerance in liver transplantation were reviewed,aiming to provide reference for the application of tolerogenic dendritic cells in immune tolerance of liver transplantation.关键词
树突状细胞/肝移植/免疫耐受/排斥反应/免疫抑制药/细胞因子/共刺激分子/交叉修饰/免疫微环境Key words
Dendritic cell/Liver transplantation/Immune tolerance/Rejection/Immunosuppressant/Cytokine/Costimulatory molecule/Cross modification/Immune microenvironment分类
医药卫生引用本文复制引用
杨志琦,李明皓..耐受性树突状细胞在肝移植免疫耐受中的作用研究进展[J].器官移植,2024,15(4):575-580,6.基金项目
宁夏自然科学基金(2021AAC03308) （2021AAC03308）
宁夏回族自治区人民医院科技创新人才项目(院党发[2023]72号) （院党发[2023]72号）
宁夏回族自治区人民医院国家自然科学基金预实验项目(2024GZRYSY0015) （2024GZRYSY0015）
