檀香木提取物对皮肤嗅觉受体的影响及功效OA北大核心CSTPCD

Olfactory receptors(OR)are a class of membrane proteins that can specifically bind to external chemicals(ligands),thereby inducing intracellular signal transmission.In this work,the impact of aging on OR,the mechanism of sandalwood extract and its clinical efficacies were studied.The relationship between age and OR was studied using reconstructed human epidermis(RHEs)at different ages.The models of senescent RHE and hair follicle dermal papilla cells were established to study the activation of OR2AT4 by sandalwood extract.The role of sandalwood extract in promoting the production of anagen-prolonging factor IGF-1 was studied using hair follicle dermal papilla cell model.The results of in vitro test showed that,the expression of OR2AT4 decreased with age.The level of OR2AT4 in senescent RHE was significantly increased by 46%after treated with 1%sandalwood extract.In addition,0.002%sandalwood extract could promote the production of IGF-1 in hair follicle dermal papilla cell model,which was significantly increased by 27%.The clinical results demonstrated that,the skin water content,skin tone,skin firmness and wrinkles were all improved after using a cream containing 2%sandalwood extract for 28 days.Hair density was significantly improved after using a scalp serum containing 2%sandalwood for 86 days.In conclusion,sandalwood extract could activate the expression of OR2AT4 and IGF-1 to improve skin aging signs and treat hair loss issue induced by hair follicle aging.