日用化学工业（中英文）2024，Vol.54Issue(7)：828-835,8.DOI:10.3969/j.issn.2097-2806.2024.07.010
檀香木提取物对皮肤嗅觉受体的影响及功效
Effect of sandalwood extract on olfactory receptor and its clinical efficacy
江月明 1鲁文嘉 1瞿欣1
作者信息
- 1. 亚什兰(中国)投资有限公司 上海创新研发中心,上海 200233
- 折叠
摘要
Abstract
Olfactory receptors(OR)are a class of membrane proteins that can specifically bind to external chemicals(ligands),thereby inducing intracellular signal transmission.In this work,the impact of aging on OR,the mechanism of sandalwood extract and its clinical efficacies were studied.The relationship between age and OR was studied using reconstructed human epidermis(RHEs)at different ages.The models of senescent RHE and hair follicle dermal papilla cells were established to study the activation of OR2AT4 by sandalwood extract.The role of sandalwood extract in promoting the production of anagen-prolonging factor IGF-1 was studied using hair follicle dermal papilla cell model.The results of in vitro test showed that,the expression of OR2AT4 decreased with age.The level of OR2AT4 in senescent RHE was significantly increased by 46%after treated with 1%sandalwood extract.In addition,0.002%sandalwood extract could promote the production of IGF-1 in hair follicle dermal papilla cell model,which was significantly increased by 27%.The clinical results demonstrated that,the skin water content,skin tone,skin firmness and wrinkles were all improved after using a cream containing 2%sandalwood extract for 28 days.Hair density was significantly improved after using a scalp serum containing 2%sandalwood for 86 days.In conclusion,sandalwood extract could activate the expression of OR2AT4 and IGF-1 to improve skin aging signs and treat hair loss issue induced by hair follicle aging.关键词
嗅觉受体/檀香木提取物/皮肤衰老/防脱/人体功效测试Key words
olfactory receptor/sandalwood extract/skin aging/anti-hair loss/human efficacy test分类
化学化工引用本文复制引用
江月明,鲁文嘉,瞿欣..檀香木提取物对皮肤嗅觉受体的影响及功效[J].日用化学工业（中英文）,2024,54(7):828-835,8.
