大黄酸通过抑制p38 MAPK磷酸化减轻UVB诱导的皮肤光老化损伤OA北大核心CSTPCD
Rhein attenuates UVB-induced skin photoaging injury by inhibiting p38 MAPK phosphorylation
揭示大黄酸(rhein)对紫外线B(UVB)诱导的皮肤光老化损伤的影响及机制.将大鼠分为6组,分别为正常对照组(NC)、UVB组、低剂量Rhein组(L-Rhein)、中剂量Rhein组(M-Rhein)、高剂量Rhein组(H-Rhein)和高剂量Rhein+p38 MAPK激动剂Anisomycin组(H-Rhein+Anisomycin).NC组大鼠仅剃毛,不照射,其他组进行UVB照射.大黄酸的给药途径为口服.大鼠共治疗8周.治疗结束后,分…查看全部>>
The study aimed to reveal the effect and mechanism of rhein on skin photoaging injury induced by ultraviolet B(UVB).Rats were divided into 6 groups:normal control group(NC),UVB group,low dose Rhein group(L-Rhein),medium dose Rhein group(M-Rhein),high dose Rhein group(H-Rhein)and high dose Rhein+p38 MAPK agonist Anisomycin group(H-Rhein+Anisomycin).Rats in the NC group were shaved without irradiation,while the other groups were irradiated with UVB.In this stu…查看全部>>
邵冠儒;张坤阳
上海现代哈森(商丘)药业有限公司,河南 商丘 476000上海现代哈森(商丘)药业有限公司,河南 商丘 476000
化学工程
大黄酸紫外线B皮肤光老化p38 MAPK抗氧化抗炎
rheinultraviolet Bskin photoagingP38 MAPKantioxidationanti-inflammation
《日用化学工业（中英文）》 2024 (7)
836-843,8
评论