3种熊果苷的安全性评价进展及其化妆品法规管理现状OA北大核心CSTPCD

α-arbutin,β-arbutin and deoxyarbutin have good whitening effect,but they are easy to produce hydroquinone under certain conditions,which has the risk of exogenous ochronosis,achromodermia,sensitization,and carcinogenesis.So their safety has attracted much attention at home and abroad.The author summarizes the safety evaluation reports of α-arbutin,β-arbutin and deoxyarbutin by the Scientific Committee on Consumer Safety(SCCS)of the European Union in recent years,as well as the supervision situation of cosmetics regulations in different countries and regions,in order to understand the safety evaluation status of arbutin and provide references for the use and supervision of arbutin in cosmetics in China.