西华大学学报（自然科学版）2024，Vol.43Issue(4)：100-109,148,11.DOI:10.12198/j.issn.1673-159X.5473
用于肿瘤免疫治疗的CD73小分子抑制剂研究进展
Research Progress in CD73 Small Molecule Inhibitors for Tumor Immunotherapy
摘要
Abstract
High levels of adenosine promote tumor growth by inhibiting the tumor immune response and stimulating tumor angiogenesis,plays an important role in immune escape and tumor progression.The large amount of adenosine is produced by the ecto-5'-nucleotidase CD73.Therefore,regulating adenosine levels by inhibiting the activity of CD73 may be a promising therapeutic strategy for future tumor immuno-therapy.Currently,research on CD73 inhibitors is still in the early stage,and no small molecule CD73 in-hibitors have been approved for marketing.This article provides a brief review of the current research status of the currently reported CD73 small molecule inhibitors in terms of their inhibitory effects and structural design,and look forward to the future research direction of CD73 small molecule inhibitors,with a view to provide more information for the development of innovative small molecule drugs targeting CD73.关键词
肿瘤免疫治疗/CD73/小分子抑制剂/核苷酸类/构效关系Key words
tumor immunotherapy/CD73/small molecule inhibitors/Nucleotide analogs/structure-activity relationship分类
药学引用本文复制引用
杨羚羚,陈曦,姜莹莹,宁香丽,李国菠..用于肿瘤免疫治疗的CD73小分子抑制剂研究进展[J].西华大学学报（自然科学版）,2024,43(4):100-109,148,11.基金项目
四川省科技厅自然科学面上项目(2023NSFSC0606) （2023NSFSC0606）
四川省科技厅青年科技创新团队项目(2023NSFSC0606). （2023NSFSC0606）
