四川医学2024，Vol.45Issue(6)：577-581,5.DOI:10.16252/j.cnki.issn1004-0501-2024.06.001
带状疱疹后遗神经痛患者治疗前后白介素10水平与疼痛程度和持续时间的相关性分析
Correlation Between Interleukin-10 Levels Before and After Treatment and Pain Severity and Duration in Patients with Postherpetic Neuralgia
摘要
Abstract
Objective To analyze correlation between interleukin-10(IL-10)and the degree and duration of pain in pa-tients with postherpetic neuralgia before and after treatment.Methods From June 2020 to December 2021,105 patients with postherpetic neuralgia admitted to our hospital were included.According to pain degree,patients were divided into mild-moderate and severe group.Age,gender and other general data were compared,and white blood cells,IL-10 and other laboratory indexes be-fore and after treatment.Patients were followed up for one year after discharge,recording the duration of pain,analyzing the correla-tion between IL-10 and the degree and duration of pain.Results During the follow-up period,4 patients lost contact and were treated as falling off.Finally,101 patients were enrolled,including 75 patients in the mild-moderate group and 26 patients in severe group.There were no significant differences in age,gender and other general data between two groups,and the percentage of white blood cells and neutrophils before and after treatment(all P>0.05).The score,duration of pain,and hypersensitive C-reactive protein(Hs-CRP)and IL-10 before treatment in the mild-moderate group were significantly lower than those in severe group(t=28.408,23.888,2.726,9.381;all P<0.05).After treatment,all indexes of patients in two groups were improved,but Hs-CRP and IL-10 in mild-moderate group were significantly lower than those in severe group(t=4.342,5.966;all P<0.05).The corre-lation analysis showed that IL-10 before and after treatment was positively correlated with the severity and duration of pain(r=0.705,0.209,0.739,0.481;all P<0.001).The linear regression showed that IL-10 and Hs-CRP before treatment were signifi-cantly correlated with the pain duration of patients(t=5.240,5.026;all P<0.05).Conclusion IL-10 before and after treat-ment would be significantly correlated with the severity and duration of pain,which could be a reliable predictor of the prognosis of patients.关键词
带状疱疹/后遗神经痛/白介素-10/疼痛Key words
herpes zoster/postherpetic neuralgia/interleukin-10/pain分类
医药卫生引用本文复制引用
迪丽白尔·塔力甫江,谢仁古丽·阿皮孜,王德全..带状疱疹后遗神经痛患者治疗前后白介素10水平与疼痛程度和持续时间的相关性分析[J].四川医学,2024,45(6):577-581,5.基金项目
新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(编号:WJWY-202125) （编号:WJWY-202125）
