四川医学2024，Vol.45Issue(6)：592-595,4.DOI:10.16252/j.cnki.issn1004-0501-2024.06.004
miR-205、血清淀粉样蛋白A联合检测在自发性早产早期评估中的价值
The Value of miR-205 and Serum Amyloid A Assay in the Early Assessment of Spontaneous Preterm Delivery
摘要
Abstract
Objective To investigate the value of serum miR-205 and serum amyloid A(SAA)in assessing early spontaneous preterm delivery.Methods 137 pregnant women of spontaneous preterm delivery(preterm group)and 165 pregnant women with normal delivery(control group)who were admitted to our hospital from January 2019 to December 2021 were selected for the study and followed up until delivery.The value of both in the assessment of early spontaneous preterm delivery was analyzed using real-time quantitative polymerase chain reaction to test the concentrations of miR-205 in serum,and the concentration of SAA was analyzed using the Genrui PA300 automated specific protein analyzer.Results MiR-205 and SAA of the preterm group were(1.51±0.43)RQ and 65.19(33.66,126.62)mg/L,which were significantly higher than those in the control group[(0.73±0.21)RQ and 8.66(5.34,11.95)mg/L]with statistically significant differences(t=19.404,Z=-10.179,P<0.05).The area under the curve of miR-205 and SAA to assess early spontaneous preterm delivery was 0.954 and 0.885 respectively.MiR-205 had a greater area under the curve and the combined diagnostic value of the two was the highest,with an area under the curve of 0.971.Conclusion MiR-205 is of high value in assessing early spontaneous preterm delivery,miR-205 and SAA can be tested in combination to improve the efficacy of assessment.关键词
miR-205/自发性早产/血清淀粉样蛋白A/风险Key words
miR-205/spontaneous preterm birth/serum amyloid A/risk分类
医药卫生引用本文复制引用
荣伟强,段娜娜,李佳欣,贾倩,陈哲,左路广..miR-205、血清淀粉样蛋白A联合检测在自发性早产早期评估中的价值[J].四川医学,2024,45(6):592-595,4.基金项目
河北省政府资助临床医学优秀人才培养项目(编号:ZF2024231) （编号:ZF2024231）
张家口市重点研发计划项目(编号:2021111D) （编号:2021111D）
