绝经后H型高血压合并骨质疏松症患者血清MCP-1、PTX3、GDF15的变化及其临床意义分析OACSTPCD

Objective To analyze changes and clinical significance of serum monocyte chemoattractant protein-1(MCP-1),pentraxin 3(PTX3)and growth differentiation factor 15(GDF15)in postmenopausal patients with H-type hypertension(HHT)and osteoporosis(OP).Methods 127 postmenopausal patients with HHT and OP who were admitted from June 2020 to May 2023 were selected as study group,another 85 postmenopausal patients with OP were selected as OP group,62 postmenopausal patients with HHT alone were selected as HHT group,and 60 healthy postmenopausal female volunteers were selected as healthy group.Serum MCP-1,PTX3,GDF15,bone mineral density of femoral neck and lumbar spine(L1～4),serum bone metabolism inde-xes[osteocalcin(BGP),type Ⅰ collagen carboxy terminal peptide β special sequence(β-CTX),type Ⅰ procollagen amino terminal propeptide(PINP)]and inflammatory factors[tumor necrosis factor α(TNF-α),interleukin-6(IL-6)]were compared among four groups.The correlation between serum MCP-1,PTX3,GDF15 and bone mineral density,serum bone metabolism indexes and in-flammatory factors were analyzed by Pearson correlation analysis.Diagnostic value of serum MCP-1,PTX3 and GDF15 in postmeno-pausal with HHT and OP were analyzed by receiver operating characteristic(ROC)curve.Results Compared with healthy group,serum MCP-1,PTX3,GDF15,BGP,β-CTX and PINP in OP group,HHT group and study group were higher,and OP group was higher than that of HHT group,study group was higher than that of OP group and HHT group(P＜0.05).Compared with healthy group,serum TNF-α and IL-6 in OP group,HHT group and study group were higher,and HHT group was higher than that of OP group,and study group was higher than that of OP group and HHT group(P＜0.05).Compared with healthy group,bone mineral density of femoral neck and lumbar spine(L1～4)in OP group,HHT group and study group were lower,and OP group was lower than that of HHT group,and study group was lower than that of OP group and HHT group(P＜0.05).Pearson correlation analysis showed that,serum MCP-1,PTX3 and GDF15 were negatively correlated with bone mineral density of femoral neck and lumbar spine(L1～4),and positively correlated with serum BGP,β-CTX,PINP,TNF-α and IL-6(P＜0.05).ROC curve analysis showed that,the AUC value of serum MCP-1,PTX3 and GDF15 combined in the diagnosis of postmenopausal with HHT and OP was 0.945,which was higher than that of single index diagnosis.Conclusion Serum MCP-1,PTX3 and GDF15 in postmenopausal pa-tients with HHT and OP increase,and are closely relate to bone mineral density of femoral neck and lumbar spine(L,～4),serum bone metabolism indexes and inflammatory factors.Combine detection of three has high value in the diagnosis of postmenopausal patients with HHT and OP.