肿瘤预防与治疗2024，Vol.37Issue(7)：571-577,7.DOI:10.3969/j.issn.1674-0904.2024.07.004
卵巢癌肺转移患者的临床特征、治疗及预后
Clinicopathological Features,Management and Prognosis of Ovarian Cancer Patients with Lung Metastasis
摘要
Abstract
Objective:To explore the clinical characteristics,treatment and prognostic factors of ovarian cancer patients with lung metastasis,and provide a basis for the diagnosis and treatment of patients with lung metastasis.Methods:Clinical data,including clinicopathological features,treatments and fol-low-ups,of ovarian cancer patients with lung metastasis admitted to Peking University People's Hospital from January 2010 to Jan-uary 2022 were retrospectively analyzed.The patients were assigned to the non-surgical group and the thoracic surgery group[in-cluding classical open thoracic surgery and video-assisted thoracic surgery(VATS)].Results:A total of 42 ovarian cancer patients with lung metastasis were collected,with including 32 cases in the non-surgical group and 10 cases in the thoracic surgery group[including open thoracic surgery(n=1)and VATS(n=9)].The average age was(52.1±13.2)years old.The pathological type was mainly high-grade serous carcinoma.The surgical modalities included wedge resection of the lung lobes,lobectomy and segmen-tectomy.All 10 surgery cases were proved to be lung metastasis by postoperative pathology.Cox univariate analysis showed that the presence of thoracic surgery(HR=0.213,95％CI:0.061～0.742,P=0.015),the presence of extrapulmonary metastasis(HR=0.208,95％CI:0.048～0.896,P=0.035),and number of pulmonary metastases(HfR=0.123,95％CI:0.016～0.923,P=0.042)were the prognostic factors of post-lung metastases overall survival(PLM-OS)in ovarian cancer patients with lung metasta-sis;the presence of thoracic surgery(HR=0.367,95％CI:0.173～0.982,P=0.046)was a prognostic factor for post-lung me-tastases progression-free survival(PLM-PFS)in ovarian cancer patients with lung metastasis.The Cox multivariate survival analysis suggested that HR values of the presence of surgery,the presence of extrapulmonary metastasis,and the number of lung metastasis for PLM-PFS were 0.495(95％CI:0.113～2.162),0.983(95％CI:0.332～2.9912)and 0.642(95％CI:0.098～4.208);and that the HR values of those factors for PLM-OS were 0.458(95％CI:0.102～2.053),0.389(95％CI:0.083～1.824)and 0.379(95％CI:0.032～4.529).Conclusion:With strict surgical indications,surgical treatment is feasible for lung metastasis of ovarian cancer.Pulmonary surgery,the presence of extrapulmonary metastasis and the number of pulmonary metastases are the prognosis factors of ovarian cancer with lung metastasis,which need to be supported by larger sample studies.关键词
卵巢癌/肺转移/手术治疗/预后Key words
Ovarian carcinoma/Lung metastasis/Surgery/Prognosis分类
医药卫生引用本文复制引用
李双双,杨帆,李小平,李赫,王悦,王琪,范晓伟,王元芬,张杨,吴燕,杨锋..卵巢癌肺转移患者的临床特征、治疗及预后[J].肿瘤预防与治疗,2024,37(7):571-577,7.基金项目
This study was supported by grants from Science and Technology Commission of Tongzhou District,Beijing(No.KJ2024CX048).北京通州区科技计划项目资助(编号:KJ2024 CX048) （No.KJ2024CX048）
