肿瘤预防与治疗2024，Vol.37Issue(7)：578-584,7.DOI:10.3969/j.issn.1674-0904.2024.07.005
山西省非贲门胃癌遗传流行病学研究
Genetic Epidemiology Study of Non-cardiac Gastric Cancer in Shanxi Province
摘要
Abstract
Objective:By conducting genetic epidemiology surveys,we explore the roles of genetic and environmental factors in the occurrence of non-cardia gastric cancer in Shanxi Province,and provide scientific basis for the etiological re-search and early prevention and treatment of gastric cancer.Methods:The data were collected by combining pedigree investi-gation with case-control study,and the data of 426 non-cardia gastric cancer patients hospitalized in Shanxi Cancer Hospital were investigated.For 379 of these cases,controls were established in a 1:1 matching manner to investigate the incidence of malignant tumors in the relatives of patients and controls,and to perform a family aggregation analysis.For 426 proband families,Li-Mantel-Gart method was used for segregation analysis,Falconer method was used to calculate heritability,and Greenwood and Yule methods were applied for birth order analysis.Results:The prevalence of non-cardia gastric cancer in the first-degree relatives of the non-cardia gastric cancer proband families was higher than that in the second-degree relatives,followed by the third-degree relatives(x2=37.065,P＜0.001),indicating that the occurrence of non-cardia gastric cancer in Shanxi Province has family aggregation.The segrega-tion ratio in the Li-Mantel-Gart method was 0.021(95％CI:0.018～0.024),and the results showed that non-cardia gastric cancer was a polygenic inherited disease.The heritability of the first-degree relatives was 11.10％±5.05％,indicating that genetic factor was one of the factors in the pathogenesis of non-cardia gastric cancer in Shanxi Province,but not the main fac-tor.Birth order analysis showed that the occurrence of non-cardia gastric cancer in Shanxi Province was related to the se-quence of birth,and it is more likely to occur in those with an earlier birth order,suggesting that environmental factors have a certain impact on the occurrence of non-cardia gastric cancer.Conclusion:The occurrence of non-cardia gastric cancer in Shanxi Province is characterized by family aggregation.Genetic factors play a certain role,but they are not the dominant fac-tors.Environmental factors have a greater influence.关键词
非贲门胃癌/遗传流行病学/分离分析/遗传度/出生顺序研究Key words
Non-cardia gastric cancer/Genetic epidemiology/Segregation analysis/Heritability/Birthday order study分类
临床医学引用本文复制引用
郭雪蓉,赵冰玉,韩小友,王媛,马朝辉..山西省非贲门胃癌遗传流行病学研究[J].肿瘤预防与治疗,2024,37(7):578-584,7.基金项目
This study was supported by grants from National Cancer Institute(No.NCI66211/CQ600211).美国国家癌症研究所(NCI)合作课题(编号:NCI66211/CQ600211) （No.NCI66211/CQ600211）
