檀双秀 1薛海燕 1张一丹 1陈桥梁 2孔文韬 1姚静 1王颖1
作者信息
- 1. 210008 南京,南京鼓楼医院/南京大学医学院附属鼓楼医院超声科
- 2. 210008 南京,南京鼓楼医院/南京大学医学院附属鼓楼医院核医学科
- 折叠
摘要
Abstract
Objective:To construct a nomogram prediction model for ductal carcinoma in situ(DCIS)of the breast based on conventional ultrasound and virtual touch tissue imaging quantification(VTIQ).Methods:A total of 165 patients(166 lesions)with intraductal breast lesions admitted to our hospital from September 2018 to October 2022 were retrospec-tively collected,including 58 cases of DCIS and 108 cases of benign lesions.The parameters relevant to shear wave velocity(SWV)in breast lesions were measured using VTIQ.Univariate and multivariate analyses were performed on age,conventional ultrasound features and SWV-related parameters to determine independent predictors of DCIS,and then a nomogram prediction model was established.The diagnostic effica-cy,accuracy and clinical practicality of the model were evaluated using the receiver operating characteristic(ROC)curve,calibration curve and decision curve analysis(DCA),and the area under the curve(AUC)in pairs were compared by Z test.Results:There were statistically significant differences in age,maximum diameter,minimum diameter,morphology,boundary,microcalcification,blood flow,BI-RADS,Vmax,Vmin,Vmean,Vmedian and coefficient of variation between the DCIS group and the benign group(P＜0.05).Age,microcalcification and Vmax were independent predictors of DCIS(OR=1.055,P=0.004;OR=4.105,P=0.002;OR=1.511,P＜0.001).The AUC value of the nomogram prediction model in the diagnosis of DCIS was 0.846,which was significantly higher than that of BI-RADS(AUC=0.742,Z=3.143,P=0.002).The calibration curve showed that the predicted probability of DCIS by the model was consistent with the actual probability for DCIS.The DCA showed that the prediction model could achieve greater clinical net benefit than BI-RADS,indicating stronger clinical practicality.Conclusion:The nomogram prediction model constructed by combining conventional ultrasound and VTIQ has high diagnostic efficacy for DCIS and can provide evidence for clinical treatment decision-making.关键词
乳腺导管原位癌/超声/弹性成像/剪切波速度/预测模型Key words
Ductal carcinoma in situ of the breast/Ultrasound/Elastography/Shear wave velocity/Prediction model分类
医药卫生
