肿瘤预防与治疗2024，Vol.37Issue(7)：600-604,5.DOI:10.3969/j.issn.1674-0904.2024.07.008
肿瘤相关性急性肾损伤的发生率及相关危险因素:单中心回顾性研究
Incidence and Risk Factors of Tumor-Associated Acute Kidney Injury:A Single-Center Retrospective Study
龙海 1刘新君 1何精 1冯颖博 1张晋才 1何晗1
作者信息
- 1. 636000 四川巴中,巴中市中心医院肾内科
- 折叠
摘要
Abstract
Objective:To analyze the occurrence of tumor-associated acute kidney injury(AKI)and explore the risk fac-tors,so as to provide evidence for early identification of tumor-related AKI high-risk groups and improve the prognosis of pa-tients.Methods:3,432 cases of malignant tumor patients in our hospital from January 1,2018 to December 31,2022 were selected as the research objects.Gender,age,basic liver and kidney function indexes and other data of the research objects were collected in the hospital data management platform,and the incidence of AKI were calculated.According to the pres-ence of AKI,the patients were assigned to the case group and the control group.Logistic regression model was used to ana-lyze the risk factors of tumor-associated AKI.Results:The incidence of tumor-associated AKI was 4.90％.Univariate analy-sis showed that the incidence of AKI in male was higher than that in female,and the risk of AKI in patients with diabetes,hy-pertension,stroke and heart failure significantly increased;the incidence of AKI in patients with hematological tumors,distant metastasis and critical condition at admission was higher;the incidence of AKI in patients with malignant tumor receiving surgical treatment was higher;the incidence of AKI was higher in patients with renal dysfunction[alanine aminotransferase≥80 U/L,aspartic transaminase≥70 μ/L,total bilirubin≥20.4 μmol/L,serum uric acid＞480 μmol/L,serum creatinine(SCr)≥ 115 μmol/L and estimated glomerular filtration rate(eGFR)≥90 mL·min-1·1.73 m-2];hypoalbuminemia(albumin＜35 g/L)and anemia(hemoglobin＜115 g/L)pa-tients with malignant tumor were more likely to develop AKI during hospitalization;in addition,various types of electrolyte disorders were associated with AKI.Multivariate logistic regression analysis found that SCr,eGFR,electrolyte disorders and hematological tumor were associated with AKI in patients with malignant tumor,and they were independent risk factors for AKI in patients with malignant tumor(P＜0.05).Conclusion:AKI is a common and serious complication in patients with malignant tumor.Timely monitoring of electrolyte level and renal functions and early identification of risk factors are helpful to early prevention and diagnosis of AKI.关键词
恶性肿瘤/急性肾损伤/危险因素/Logistic回归模型/回顾性研究Key words
Malignant tumor/Acute kidney injury/Risk factors/Logistic regression model/Retrospective study分类
临床医学引用本文复制引用
龙海,刘新君,何精,冯颖博,张晋才,何晗..肿瘤相关性急性肾损伤的发生率及相关危险因素:单中心回顾性研究[J].肿瘤预防与治疗,2024,37(7):600-604,5.
