山东中医药大学学报2024，Vol.48Issue(4)：434-439,6.DOI:10.16294/j.cnki.1007-659x.2024.04.008
基于孟德尔随机化探讨原发性甲状腺功能减退症与肠易激综合征的因果关系及相关病机
Analysis on Causality and Pathogenesis of Primary Hypothyroidism and Irritable Bowel Syndrome Based on Mendelian Randomization
摘要
Abstract
Objective:To investigate the causal relationship between primary hypothyroidism and irritable bowel syndrome(IBS)by using Mendelian randomization(MR)method,and to analyze the pathogenesis characteristics of traditional Chinese medicine in both.Methods:Genome-wide association study(GWAS)data were used for MR analysis,with primary hypo-thyroidism as the exposure factor and IBS as the outcome variable.Inverse weighting of variance(IVW)was adopted as the main research index,and MR-Egger,weighted median method,weighted model method and other methods were adopted to ensure the reliability of MR.Heterogeneity test,sensitivity analysis and pleiotropy analysis were carried out to ensure the stability of the study results.Results:Primary hypothyroidism had a causal relationship with IBS,IVW(OR=1.08,95％CI was 1.01～1.16,P=0.02).IBS was causally associated with primary hypothyroidism,IVW(OR=1.11,95％CI was 1.03～1.20,P=0.006).Conclusions:Primary hypothyroidism can increase the risk of IBS,and IBS can also increase the risk of primary hypothyroidism.Liver stagnation spleen deficiency,kidney yang deficiency were main pathogenesis of Traditional Chinese Medicine of mutual causality and comorbidity between them.关键词
原发性甲状腺功能减退症/肠易激综合征/孟德尔随机化/肝郁脾虚/肾阳亏虚/治未病Key words
primary hypothyroidism/irritable bowel syndrome/Mendelian randomization/liver stagnation spleen deficiency/kidney yang deficiency/preventive treatment of disease分类
中医学引用本文复制引用
宋帅,杜冬青,贾聪聪,周悦,马玉侠..基于孟德尔随机化探讨原发性甲状腺功能减退症与肠易激综合征的因果关系及相关病机[J].山东中医药大学学报,2024,48(4):434-439,6.基金项目
山东省自然科学基金面上项目(编号:ZR2021MH373) （编号:ZR2021MH373）
