远志毒性及其炮制品研究进展OACSTPCD

Yuanzhi(Polygalae Radix)has the efficacy of tranquilizing mind and improving intelligence,relieving cough and expelling phlegm,dispersing abscesses and dissipating mass,however,its gastrointestinal toxicity is obvious.The author combed the literature and found that after processed with Fengmi(Mel),Gancao(Glycyrrhizae Radix et Rhizoma),Shengjiang(Zingiberis Rhizoma Recens)and Houpo(Magnolia Officinalis Cortex),not only the toxicity of Yuanzhi could be reduced,but also the function of tranquilizing heart and calming mind,expelling phlegm and promoting resuscitation could be retained to expand the scope of clinical application.The toxic constituents of Yuanzhi are Yuanzhi saponins,which are easy to cause gastroin-testinal adverse reactions.The main efficacy of honey processed Yuanzhi is to relieve cough and expel phlegm,and the main active constituents are Yuanzhi saponins.The main efficacy of processed Yuanzhi is to tranquilize mind,and the main active constituents are oligosaccharides.The main efficacy of ginger processed Yuanzhi is to regulate qi movement,and the main active constituents are volatile oils.The main efficacy of Houpo processed Yuanzhi is to harmonize stomach and activate spleen,and the main active constituents are magnolol and Xiye Yuanzhi saponin.The clinical efficacy of Yuanzhi is precise,but its toxicity cannot be ignored.It is urgent to conduct more in-depth research on the toxicity of Yuanzhi and its processed products,so as to provide references for safe use of Yuanzhi in clinic.There are 68 references in total.