陕西中医2024，Vol.45Issue(7)：893-896,4.DOI:10.3969/j.issn.1000-7369.2024.07.006
针刺足三里对小鼠术后肠麻痹的作用机制
Mechanism of acupuncture at Zusanli point in treating postoperative ileus
摘要
Abstract
Objective:Study aims to explore effects of acupuncture at Zusanli acupoint on postoperative ileus and its information transmission mechanism.Methods:Ten wild-type mice and ten Toll like receptor 4 gene knockout mice were used to construct postoperative ileus models.The postoperative gastrointestinal motility and intestinal mu-cosal damage were compared.Twenty wild-type mice were used to construct postoperative ileus model,which were randomly divided into electroacupuncture Zusanli acupoint group and control group,with ten mice in each group.The electroacupuncture Zusanli acupoint group were continuously stimulated with electroacupuncture at Zusanli acupoint 4 times at 6 h,24 h,48 h,and 72 h after modeling.The control group were connected to electroacupuncture instru-ment but not given electrical stimulation.The gastrointestinal motility function,levels of inflammatory factors in small intestine tissue,and key molecule Toll like receptor 4 related to Toll like receptor pathways in both groups were detected TRAF6 and JNK expression.Results:Compared with wild-type mice,Toll like receptor 4 gene knockout mice showed improved gastrointestinal motility,down-regulated expression of inflammatory factors in small intestine tissue,and milder intestinal mucosal damage.Stimulating Zusanli acupoint with electroacupuncture could improve gastrointestinal motility,reduce expression levels of inflammatory factors in small intestine tissue,and down-regulate the expression levels of Toll like receptor 4 related factorsTLR4,TRAF6 and JNK.Conclusion:Electroacupuncture at Zusanli acupoint could alleviate postoperative intestinal paralysis,and the Toll like receptor 4 signaling pathway might play key regulatory role in the process.关键词
术后肠麻痹/针刺/电针/足三里/Toll样受体4/围手术期Key words
Postoperative ileus/Acupuncture/Electroacupuncture/Zusanli/Toll like receptor 4/Perioperative period分类
医药卫生引用本文复制引用
周丹丹,马晨,何伟坤,范哲..针刺足三里对小鼠术后肠麻痹的作用机制[J].陕西中医,2024,45(7):893-896,4.基金项目
陕西省自然科学基金资助青年项目(2021-JQ937) （2021-JQ937）
