陕西中医2024，Vol.45Issue(8)：1052-1055,1060,5.DOI:10.3969/j.issn.1000-7369.2024.08.009
参芪真武汤加味治疗原发性肾病综合征疗效及对患者肾功能、微炎状态、凝血纤溶功能的影响
Effect of Shenqi Zhenwu decoction on primary nephrotic syndrome and its influence on renal function,micro-inflammatory state,coagulation and fibrinolytic function
摘要
Abstract
Objective:To explore the effect of Shenqi Zhenwu decoction in the treatment of primary nephrotic syndrome and its influence on renal function,micro-inflammatory state,coagulation and fibrinolysis function.Methods:110 patients with primary nephrotic syndrome with spleen kidney yang deficiency syndrome were selected.They were divided into two groups according to the treatment plan,with 55 cases in the observation group and 55 cases in the control group.The control group received routine symptomatic treatment,while the observation group received modi-fied Shenqi Zhenwu decoction treatment on the basis of the control group.Both groups were treated continuously for 8 weeks.Compare the total effective rate and incidence of adverse reactions between two groups.The traditional Chi-nese medicine syndrome scores,renal function[24-hour urine protein quantification(24 hTP),blood albumin(ALB),urea nitrogen(BUN),serum creatinine(Cr)],micro inflammatory status[high-sensitivity C-reactive protein(hs-CRP),interleukin-21(IL-21),interleukin-13(IL-13)],coagulation and fibrinolytic function[fibrinogen(FIB),D-dimer(D-D)]were observed before and after treatment.Results:The total effective rate of the observation group was 90.91%,which was significantly higher than 76.36%of the control group(P<0.05).After treatment,edema,pale complexion,cold limbs,lumbar debility,evil cold or warm score in the observation group were lower than the control group(all P<0.05).The level of ALB in the observation group was higher than that in the control group,and the 24 hTP,BUN and Cr were lower than those in the control group(all P<0.05).After treatment,the IL-13 in the observation group was higher than that in the control group,and the hs-CRP and IL-21 were lower than those in the control group(all P<0.05).FIB and D-D levels in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P<0.05).There was no significant difference in adverse reactions(P>0.05).Conclusion:The modified Shenqi Zhenwu decoction in the treatment of pri-mary nephrotic syndrome with spleen-kidney yang deficiency can improve the clinical effect,reduce the TCM syn-drome score,promote the improvement of renal function and coagulation and fibrinolytic function,reduce the micro-inflammatory state of the body,and has good safety.关键词
原发性肾病综合征/参芪真武汤/脾肾阳虚证/肾功能/微炎症状态/凝血纤溶功能Key words
Primary nephrotic syndrome/Shenqi Zhenwu decoction/Spleen and kidney yang deficiency syn-drome/Renal function/Micro-inflammatory state/Coagulation and fibrinolytic function分类
医药卫生引用本文复制引用
任剑雄,韦淇元,梁建亮..参芪真武汤加味治疗原发性肾病综合征疗效及对患者肾功能、微炎状态、凝血纤溶功能的影响[J].陕西中医,2024,45(8):1052-1055,1060,5.基金项目
广东省科技厅科技计划项目(2022A0505020029) （2022A0505020029）
广东省佛山市科学技术局自筹经费类科技创新项目(2220001005371) （2220001005371）
