陕西中医2024，Vol.45Issue(8)：1056-1060,5.DOI:10.3969/j.issn.1000-7369.2024.08.010
益气护肾方佐治慢性肾衰竭3～5期肾气虚夹瘀临床研究
Clinical efficacy of Yiqi Hushen decoction adjuvant therapy on patients with stage 3～5 chronic renal failure with syndrome of kidney deficiency and blood stasis
摘要
Abstract
Objective:To observe the clinical efficacy of Yiqi Hushen decoction in the adjuvant treatment of pa-tients with stage 3～5 chronic renal failure(CRF)with syndrome of kidney deficiency and blood stasis.Methods:106 patients with stage 3～5 CRF with syndrome of kidney deficiency and blood stasis were selected as the research sub-jects.According to the random number table method,they were divided into conventional group(conventional treat-ment,acupoint application and rectal drip of traditional Chinese medicine)and Yiqi Hushen group(Yiqi Hushen de-coction on the basis of conventional group),with 53 cases in each group.The two groups were compared in terms of clinical efficacy,TCM symptoms scores,renal function[estimated glomerular filtration rate(eGFR),serum creati-nine(Scr),blood urea nitrogen(BUN),24-hour urinary protein quantification(24 h-UPRO)],inflammatory factors[granulocyte-macrophage colony-stimulating factor(GM-CSF),leukotactin-1(LKN-1),tumor necrosis factor-α(TNF-α)]and oxidative stress indicators[advanced glycation end products(AGEs),malondialdehyde(MDA),reac-tive oxygen species(ROS)]before and after treatment.Results:The total effective rate in Yiqi Hushen group was higher compared to conventional group(P<0.05).The scores of TCM syndromes were declined in groups after treatment,and the scores in Yiqi Hushen group were lower than those in conventional group(all P<0.05).The lev-els of Scr,BUN and 24 h-UPRO were reduced in both groups after treatment,while the level of eGFR was enhanced(all P<0.05),and there were statistical differences between groups after treatment(all P<0.05).The levels of GM-CSF,LKN-1 and TNF-αwere declined in both groups after treatment,and the levels after treatment were lower in Yiqi Hushen group than those in conventional group(all P<0.05).After treatment,the levels of AGEs,MDA and ROS in the two groups were lowered,and the Yiqi Hushen group had lower AGEs,MDA and ROS(all P<0.05).Conclusion:Yiqi Hushen decoction can regulate the levels of inflammatory factors,relieve the oxidative stress re-sponse and renal injury,improve the symptoms and enhance the efficacy in the adjuvant treatment of patients with stage 3～5 CRF with syndrome of kidney deficiency and blood stasis.关键词
慢性肾衰竭/肾气虚夹瘀/中医症状积分/肾功能/氧化应激/炎性因子Key words
Chronic renal failure/Kidney deficiency and blood stasis/TCM symptoms scores/Renal function/Oxidative stress/Inflammatory factors分类
医药卫生引用本文复制引用
刘文君,王亿平,吕伟,刘诗富..益气护肾方佐治慢性肾衰竭3～5期肾气虚夹瘀临床研究[J].陕西中医,2024,45(8):1056-1060,5.基金项目
安徽省重点研究与开发计划项目(202104J07020014) （202104J07020014）
