微波针刺配合生血润肤饮治疗寻常型银屑病的疗效观察OACSTPCD
Observation of the therapeutic efficacy of microwave needling combined with Shengxue Runfu decoction in the treatment of psoriasis vulgaris
目的 观察微波针刺配合生血润肤饮治疗寻常型银屑病的临床疗效.方法 将 100 例寻常型银屑病患者随机分为对照组和观察组,每组50 例.对照组采用口服生血润肤饮加减治疗,观察组在对照组基础上加用微波针刺治疗.观察两组治疗前后各项中医症候(红斑、鳞屑、浸润增厚及皮损面积)积分、银屑病面积和严重程度指数(psoriasis area and severity index,PASI)评分、血清生物标志物[血管生成素 2(angiopoietin 2,ANGPT2)、血管内皮生长因子受体 3(vascular endothelial growth factor receptor-3,VEGFR-3)]水平及免疫功能各项指标(CD4+、CD8+、CD4+/CD8+)的变化情况,并比较两组临床疗效及不良反应发生率.结果 观察组总有效率为 96.0%,明显高于对照组的 76.0%(P＜0.05).两组治疗后各项中医症候积分、PASI 评分、CD8+及血清ANGPT2、VEGFR-3 水平均较同组治疗前显著下降,CD4+、CD4+/CD8+均较同组治疗前显著上升,差异均具有统计学意义(P＜0.05).观察组治疗后各项中医症候积分、PASI评分、CD8+及血清ANGPT2、VEGFR-3水平均明显低于对照组,CD4+、CD4+/CD8+均明显高于对照组,差异均具有统计学意义(P＜0.05).对照组治疗期间不良反应发生率为4.0%,观察组为 6.0%,两组比较差异无统计学意义(P＞0.05).结论 微波针刺配合生血润肤饮是一种治疗寻常型银屑病的有效方法,能有效改善患者临床症状,降低血清ANGPT2及VEGFR-3 水平,增强免疫功能,且安全可靠.
Objective To observe the clinical efficacy of microwave needling combined with Shengxue Runfu decoction in the treatment of psoriasis vulgaris.Method A total of 100 cases of psoriasis vulgaris were randomly divided into a control group and an observation group,50 cases in each group.The control group was treated with Shengxue Runfu decoction orally,while the observation group was treated with microwave needling on the basis of the control group.Before and after the treatment,the TCM symptom(erythema,scales,infiltrating thickening and lesion area)scores,psoriasis area and severity index(PASI)scores,serum biomarkers[angiopoietin 2(ANGPT2),vascular endothelial growth factor receptor-3(VEGFR-3)]levels and immune function indicators(CD4﹢,CD8﹢,CD4﹢/CD8﹢)were observed in the two groups,and the clinical efficacy and incidence of adverse reactions were compared between the two groups.Result The total effective rate of the observation group was 96.0%,which was significantly higher than that of the control group,which was 76.0% (P＜0.05).The TCM symptom scores,PASI scores,CD8﹢,serum ANGPT2 and VEGFR-3 levels of both groups decreased significantly,while CD4﹢ and CD4﹢/CD8﹢ increased significantly,the difference was statistically significant(P＜0.05).In the observation group,the TCM symptom scores,PASI scores,CD8﹢ and serum ANGPT2 and VEGFR-3 levels were significantly lower than those in the control group,and CD4﹢ and CD4﹢/CD8﹢ were significantly higher than those in the control group,with statistically significant differences(P＜0.05).The incidence rate of adverse reactions during treatment was 4.0% in the control group and 6.0% in the observation group,and the difference between the two groups was not statistically significant(P＞0.05).Conclusion Microwave needling combined with Shengxue Runfu decoction is an effective treatment for psoriasis vulgaris,which can effectively improve the clinical symptoms of patients,reduce the serum ANGPT2 and VEGFR-3 levels,enhance the immune function,and the safety is reliable.
阮波;李铭航;叶碧珍;薛爱国;罗树雄
广州中医药大学东莞医院,东莞 523000东莞市第六人民医院,东莞 523000
中医学
针灸疗法银屑病微波针刺血管生成素2血管内皮生长因子受体3针药并用
AcupuncturePsoriasisMicrowave needlingAngiopoietin 2Vascular endothelial growth factor receptor 3Combination of acupuncture and medication
《上海针灸杂志》 2024 (007)
785-790 / 6
广东省中医药局科研项目(20202038)
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