世界中医药2024，Vol.19Issue(10)：1455-1459,5.DOI:10.3969/j.issn.1673-7202.2024.10.013
基于肠道屏障探讨"脾主为卫"在溃疡性结肠炎发病与治疗中的作用机制
Mechanism and Clinical Application of Spleen Being in Charge of the Defensive Function in Ulcerative Colitis from the Perspective of Intestinal Barrier
摘要
Abstract
Ulcerative colitis(UC)is characterized by the impaired intestinal barrier,with the clinical manifestations including per-sistent inflammation,ulceration of the rectal mucosa,and recurrent inflammatory bowel disease.The spleen is closely related to the intestinal barrier,and the dysfunction of the spleen being in charge of the defensive function is the main pathogenesis of UC.How-ever,the microscopic mechanism of this pathogenesis remains unclear.The intestinal barrier is similar to the spleen being in charge of the defensive function.The impairment of the intestinal barrier is mutually causal with UC.The TCM theory of spleen being in charge of the defensive function can be explained from the perspective of intestinal barrier.The modern medical therapy for UC re-mains to be developed,and drug therapies have limitations such as side effects and aggravation after drug withdrawal.The TCM treatment method of replenishing qi and invigorating spleen based on the TCM theory of spleen being in charge of the defensive function can restore the intestinal barrier and promote mucosal healing without inducing side effects,which has a significant clinical value for promoting the healing and preventing the recurrence of UC.关键词
溃疡性结肠炎/肠道屏障/肠道黏膜免疫/肠道黏液层/肠道菌群/中医药/脾主为卫/益气健脾Key words
Ulcerative colitis(UC)/Intestinal barrier/Intestinal mucosal immunity/Intestinal mucus layer/Intestinal flora/TCM/Spleen being in charge of the defensive function/Replenishing qi and invigorating spleen分类
医药卫生引用本文复制引用
张安琪,吴玉琦,姚海强,万瑾毅..基于肠道屏障探讨"脾主为卫"在溃疡性结肠炎发病与治疗中的作用机制[J].世界中医药,2024,19(10):1455-1459,5.基金项目
国家自然科学基金项目(82374324,81973714) （82374324,81973714）
中华中医药学会"青年人才托举工程"项目(CACM-2019-QNRC2-A01) （CACM-2019-QNRC2-A01）
中央高校基本科研业务费资助项目(2020-JYB-XJSJJ-03,2022-JYB-JBZR-009) （2020-JYB-XJSJJ-03,2022-JYB-JBZR-009）
