世界中医药2024，Vol.19Issue(10)：1505-1509,5.DOI:10.3969/j.issn.1673-7202.2024.10.021
基于脑源性神经营养因子信号通路探讨针刺干预抑郁症的作用机制
Acupuncture Treatment of Depression via Brain-derived Neurotrophic Factor Signaling Pathway
摘要
Abstract
The basic studies about the acupuncture treatment of depression via regulating the brain-derived neurotrophic factor(BDNF)signaling pathway were retrieved from databases and reviewed.The available studies show that acupuncture intervenes in depression by regulating the BDNF/tropomyosin-related kinase B(TrKB)and tissue plasminogen activator(tPA)/BDNF signaling pathways to modulate synaptic plasticity and BDNF epigenetics.However,most of the available studies lack the reverse verification of the BDNF pathway,and the studies about the pathway or mechanism are limited to the classical upstream and downstream tar-gets.In addition,the specific mechanism between acupoints,BDNF pathway,and disease target organs remains to be elucidated.关键词
抑郁症/针刺/脑源性神经营养因子/酪氨酸激酶受体B/组织纤溶酶激活因子/突触可塑性/表观遗传/作用机制Key words
Depression/Acupuncture/Brain-derived neurotrophic factor/Tropomyosin-related kinase B/Tissue plasminogen ac-tivator/Synaptic plasticity/Epigenetics/Mechanism分类
医药卫生引用本文复制引用
董娉,吕世盟,毕德众,高明周,马月香..基于脑源性神经营养因子信号通路探讨针刺干预抑郁症的作用机制[J].世界中医药,2024,19(10):1505-1509,5.基金项目
国家自然科学基金面上项目(81974553)——从中枢PAG区对ALLO波动敏感性探讨中药舒郁胶囊对PMDD肝气郁证干预机制 （81974553）
国家自然科学基金青年科学基金项目(82204958)——L-VGCC/Ca2+级联信号通路调控GABAAR在PMDD肝气逆证易怒、愤怒中的作用及机制研究 （82204958）
