生命科学仪器2024，Vol.22Issue(3)：69-70,74,3.DOI:10.11967/2024220622
富马酸丙酚替诺福韦对HBV感染免疫耐受期孕妇母婴阻断效果及安全性评价
Evaluation of the Maternal And Infant Blockade Effect And Safety of Propofol Tenofovir Fumarate on HBV Infection in Immunotolerant Pregnant Women
摘要
Abstract
Objective:To Objective To study the blocking effect and safety of propofol fumarate on pregnant women infected with hepatitis B virus(HBV)in immune tolerance period.Methods:From January 2021 to January 2023,28 pregnant women with HBV infection in immune tolerance period were selected and divided into tenofovir dipiv-oxil fumarate(TDF)group and tenofovir dipivoxil fumarate(TAF)group according to the antiviral scheme.HBV DNA load,glomerular filtration rate(eGFR)、urinary β2 microglobulin and the incidence of adverse reactions were compared between the two groups.Results:HBV DNA in the two groups decreased after treatment compared with that before treatment,P<0.05;The eGFR of the two groups after treatment was compared with that before treat-ment,P>0.05;After treatment,urine β2 microglobulin in TDF group was significantly higher than that before treatment,and it was higher than that in TAF group,P<0.05.The incidence of adverse reactions between the two groups was compared,P>0.05.The detection results of HBV DNA、HBsAg and HBeAg in newborns of both groups were negative.Conclusion:Propofovir fumarate is effective in the treatment of pregnant women with immune tolerance to HBV infection,which can effectively reduce their HBV DNA,obtain a good mother-to-child bloc-king effect,and is safe for pregnant women's kidneys.关键词
乙型肝炎病毒感染/耐受期孕妇/富马酸丙酚替诺福韦/母婴阻断Key words
Hepatitis B virus/Pregnant women during the tolerance period/Propofol tenofovir fumarate/Maternal and infant blockade分类
医药卫生引用本文复制引用
张丽媛,符芳翔,郑小静,李娟,杜永国..富马酸丙酚替诺福韦对HBV感染免疫耐受期孕妇母婴阻断效果及安全性评价[J].生命科学仪器,2024,22(3):69-70,74,3.基金项目
海南省卫生健康行业科研项目21A200262 （）
