生命科学仪器2024，Vol.22Issue(3)：71-74,4.DOI:10.11967/2024220623
隐匿性乙肝病毒感染献血者HBV分子生物学特性及追踪研究
HBV Molecular Biological Characteristics And Follow-up of Occult Hepatitis B Virus Infection in Voluntary Blood Donors
摘要
Abstract
Objective:To explore the occult hepatitis B virus infection in voluntary blood donors of Jinan and Binzhou.Methods:Blood samples collected from voluntary blood donors during 2020 to 2023 in Jinan and Binzhou were tested by ELISA twice and NAT once.Then HBsAg and HBcAb were analyzed on HBV DNA reactive sam-ples implicated in nonreactive ELISA.Call these blood donors to investigate the status of hepatitis B vaccine immu-nization and HBV infection of their family members.HBV DNA and five hepatitis B items were analyzed for follow-up blood donors in order to get the changes of serological and molecular biological characteristics.Results:285 out of 786000 blood samples were detected positive by NAT but were non-reactive in the primary ELISA screening,and 237(83.16%)of them were detected HBcAb positive.36 blood donors were followed up.Based on the results of follow-up tests,32 were identified as occult hepatitis B virus infection(OBI),2 as"window period"HBV infec-tion,2 as false positive in initial NAT.Conclusion:Vaccination has effectively reduced the rate of hepatitis B infec-tion.NAT can detect the OBI and shorten the"window period""effectively,so then reduce residual risk of transfu-sion transmissible infection.关键词
献血者/隐匿性乙肝病毒感染/核酸检测/乙肝疫苗接种Key words
Blood donors/Occult hepatitis B virus infection/NAT/hepatitis B vaccination分类
医药卫生引用本文复制引用
肖晨..隐匿性乙肝病毒感染献血者HBV分子生物学特性及追踪研究[J].生命科学仪器,2024,22(3):71-74,4.基金项目
课题基金:山东省医药卫生科技发展计划项目(2019WS542) （2019WS542）
