生物加工过程2024，Vol.22Issue(4)：355-366,12.DOI:10.3969/j.issn.1672-3678.2024.04.001
变构蛋白的调控机制及其分子设计的研究进展
Advances in the mechanism of allosteric proteins and their molecular design
摘要
Abstract
Allosteric proteins are a class of proteins with specific allosteric effects,and the exploration of their variousness allosteric mechanisms greatly enriches the activity and selectivity of the functional library of proteins.The investigation of the allosteric effects and their regulatory mechanisms is of great significance for the expansion of protein functions,drug discovery and signal transmit.We summarize recent the functions and classification of allosteric proteins,regulatory mechanisms,structural analysis,rational prediction of allosteric sites,and modification of artificial allosteric proteins,and comprehensively analyze the On-Off conformational regulation,cooperative allosteric regulation,and indirect allosteric regulation mechanisms of allosteric proteins,current research difficulties and possible corresponding strategies so as to provide theoretical support for the rational design of allosteric protein.关键词
变构蛋白/变构调节机制/结构解析/人工变构蛋白Key words
allosteric protein/allosteric regulatory mechanism/structural analysis/artificial allosteric protein分类
生物科学引用本文复制引用
曹伟洁,陈林浩,庞亚如,成旭,吕波..变构蛋白的调控机制及其分子设计的研究进展[J].生物加工过程,2024,22(4):355-366,12.基金项目
国家重点研发计划(2018YFA0901800) （2018YFA0901800）
天津合成生物技术创新能力提升项目(TSBICIP-CYFH-002) （TSBICIP-CYFH-002）
