生物技术通报2024，Vol.40Issue(7)：78-89,12.DOI:10.13560/j.cnki.biotech.bull.1985.2024-0020
动物细胞永生化研究进展
Research Progress in the Immortalization of Animal Cells
摘要
Abstract
Cell immortalization refers to breaking through the limitations of primary cell aging,extending cell lifespan,and achieving unlimited cell replication and proliferation through various means and methods,which is a hot and difficult research topic in the current biomedical field.Immortalized cell lines can be used for the development of biological products,exploration of aging mechanisms to extend life,etc.However,due to the limited variety of immortalized cells,relatively difficult immortalization technology,tumor risk,and animal welfare ethics,it still cannot meet the research and developing needs.The purpose of immortalizing cells is not only to permanently preserve the genetic resources of animal cells,but also to provide support for the diagnosis and treatment of various diseases,as well as to develop cell matrix for vaccines.This article reviews the latest progresses in the principles,mechanisms,and methods of immortaling animal cells,providing reference for future biomedical research and applications.关键词
动物细胞/细胞永生化/永生化机制/永生化方法Key words
animal cells/cell immortalizing/immortalization mechanism/immortalization method引用本文复制引用
张震宇,靳莉武,王婧尊,田玲,乔自林,杨迪,阿依木古丽·阿不都热依木..动物细胞永生化研究进展[J].生物技术通报,2024,40(7):78-89,12.基金项目
甘肃省科技计划重点研发项目(23YFFA0071),中央高校基本科研业务费项目(31920220070,31920230001),甘肃省科技计划项目(22JR11RA239) （23YFFA0071）
