TRIM59对人下咽癌细胞增殖、凋亡、侵袭和迁移的影响OACSTPCD
Effect of TRIM59 on proliferation,apoptosis,invasion and migration of human hypopharyngeal cancer cells
目的 探讨三结构域蛋白59(tripartite motif containing 59,TRIM59)对下咽癌细胞Fadu的生物学行为的影响及其机制.方法 通过肿瘤免疫估计资源数据库2.0(TIMER2)了解TRIM59在不同类型癌症中的表达情况,初步评估其在头颈部肿瘤中的表达差异.培养下咽癌细胞株Fadu,随机分为:实验组(si-TRIM59-1组,si-TRIM59-2组,si-TRIM59-3组)和对照组(NC组).通过实时定量PCR法检…查看全部>>
Objective To investigate the effects of tripartite motif containing 59(TRIM59)on the biological behaviors of hypopharyngeal cancer cells Fadu and its mechanism.Methods The expression of TRIM59 in different types of cancer was investigated through the Tumor Immune Estimation Resource database 2.0(TIMER2),and its expression difference in head and neck tumors was initially eva-luated.Nasopharyngeal carcinoma Fadu cells were cultured and randomly divided into ex…查看全部>>
邵渝欢;马赛菲;王文忠
蚌埠医科大学第一附属医院耳鼻咽喉头颈外科,蚌埠 233000蚌埠医科大学第一附属医院耳鼻咽喉头颈外科,蚌埠 233000蚌埠医科大学第一附属医院耳鼻咽喉头颈外科,蚌埠 233000
临床医学
下咽癌JAK/STAT通路TRIM59增殖迁移凋亡
hypopharyngeal carcinomaJAK/STAT pathwayTRIM59proliferationmigrationapoptosis
《山西医科大学学报》 2024 (6)
698-706,9
安徽省高等学校自然科学研究项目(KJ2020A0568)
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