山西医科大学学报2024，Vol.55Issue(6)：763-766,4.DOI:10.13753/j.issn.1007-6611.2024.06.013
微波消解-电感耦合等离子体质谱法同时测定阿拉伯胶中6种金属元素含量
Determination of six heavy metal elements in Acacia by ICP-MS after microwave digestion
摘要
Abstract
Objective To establish an microwave digestion-inductively coupled plasma mass spectrometry(ICPMS)method for simul-taneously determining the contents of six heavy metal elements in Acacia.Methods The Acacias were digested with nitric acid by the microwave digestion,and then the contents of Hg,V,Cd,Co,As and Pb were determined by inductively coupled plasma mass spec-trometry(ICP-MS).Results The linear equation was Y=2 500.668 3ρ+370.020 0(n=6,R2=0.999 6)for Hg,Y=4 388.276 3ρ+25.000 0(n=6,R2=0.999 1)forV,Y=1 752.864 5ρ+0.000 1(n=6,R2=0.999 1)for Cd,Y=12 593.112 3ρ+25.000 0(n=6,R2=0.998 9)for Co,Y=717.067 0ρ+15.000 0(n=6,R2=0.998 6)for As,and Y=7 612.563 7ρ+170.010 0(n=6,R2=0.9995)for Pb.The method showed good precision and repeatability in the linearity range of 0-100 ng/mL for these six elements.The detection limits of Hg,V,Cd,Co,As and Pb were 0.000 5 mg/kg,0.000 4 mg/kg,0.000 2 mg/kg,0.000 3 mg/kg,0.001 0 mg/kg,0.000 4 mg/kg,respectively.The quantitation limits of Hg,V,Cd,Co,As,Pb were 0.001 7 mg/kg,0.001 2 mg/kg,0.001 8 mg/kg,0.001 0 mg/kg,0.003 4 mg/kg,0.001 3 mg/kg,respectively.The average recoveries of the six elements were 91.12％-104.60％.Conclusion ICP-MS method is specific,convenient and fast for determination of trace mental elements content in Acacia.关键词
阿拉伯胶/金属元素/电感耦合等离子体质谱法/药用辅料/国际人用药品注册技术协调会元素杂质指导原则Key words
Acacia/trace metal elements/ICP-MS/pharmaceutical excipient/ICH Q3D分类
医药卫生引用本文复制引用
李鑫,徐向炜,姚羽..微波消解-电感耦合等离子体质谱法同时测定阿拉伯胶中6种金属元素含量[J].山西医科大学学报,2024,55(6):763-766,4.基金项目
国家药品抽检计划阿拉伯胶专项项目(87号) （87号）
