陕西医学杂志2024，Vol.53Issue(7)：931-935,5.DOI:10.3969/j.issn.1000-7377.2024.07.014
老年冠心病患者血清脂联素、生长素释放肽水平与血小板聚集率及主要不良心脏事件相关性分析
Correlation analysis of serum APN and Ghrelin levels with platelet aggregation rate and major adverse cardiac events in elderly patients with coronary heart disease
摘要
Abstract
Objective:To investigate the correlation between serum adiponectin(APN),Ghrelin levels,platelet aggregation rate(PAG)and major adverse cardiac events(MACE)in elderly patients with coronary heart disease(CHD).Methods:A total of 83 elderly patients with CHD were selected as the case group,and 72 healthy subjects were selected as the control group.After admission,the general data of all subjects were collected,and their fasting blood glucose,blood lipid and other biochemical indicators were detected.Serum APN and Ghrelin levels were detec-ted by enzyme-linked immunosorbent assay.The correlation between PAG and serum APN、Ghrelin levels was ana-lyzed by turbidimetry with platelet aggregator.The patients were followed up for 12 weeks after discharge,the occur-rence of MACE was recorded,and the correlation between serum APN、Ghrelin level and MACE was analyzed.Results:There were significant differences in total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),blood uric acid(UA),left ventricular end-diastolic inner diameter(LVEDD)and left ventricular ejection fraction(LVEF)between CHD group and control group(all P＜0.05).Compared with the control group,the levels of APN and Ghrelin in CHD group were significantly decreased(all P＜0.05).Com-pared with the control group,PAG in CHD group was significantly increased(P＜0.05).Pearson correlation analysis showed that serum APN and Ghrelin levels were significantly negatively correlated with PAG in CHD patients(r=-0.792,-0.578,all P＜0.05).Among the 83 CHD patients,26 had MACE.Compared with the patients without MACE,there were significant differences in HDL、LVEDD、LVEF、APN and Ghrelin between the two groups(all P＜0.05).Logistic regression analysis showed that HDL、LVEF、APN and Ghrelin were protective factors for MACE occurrence(all P＜0.05).Conclusion:The serum levels of APN and Ghrelin levels in elderly CHD patients are significantly reduced,and are closely related to platelet aggregation rate and prognosis.Low levels of APN and Ghrelin can reflect the risk of MACE in CHD patients to a certain extent.关键词
冠心病/脂联素/生长素释放肽/血小板聚集率/主要不良心脏事件/相关性Key words
Coronary heart disease/APN/Ghrelin/Platelet aggregation rate/Major adverse cardiac events/Correlation分类
医药卫生引用本文复制引用
蔡敏一,赵德强,于宏梅,高海超,汪蔚青..老年冠心病患者血清脂联素、生长素释放肽水平与血小板聚集率及主要不良心脏事件相关性分析[J].陕西医学杂志,2024,53(7):931-935,5.基金项目
河北省医学科学研究重点课题计划项目(20211799) （20211799）
