武警医学2024，Vol.35Issue(7)：582-587,592,7.
慢性阻塞性肺疾病患者胸大肌CT参数与肺功能及疾病严重程度的关系
Relationship between pectoralis major muscle CT parameters and lung function and dis-ease severity in patients with chronic obstructive pulmonary disease
摘要
Abstract
Objective To analyze the relationship between pectoral major muscle area(PMA)and pectoral major muscle density(PMD)measured by computed tomography(CT)and lung function and disease severity in patients with chronic obstructive pulmonary disease(COPD)based on generalized linear model.Methods Clinical data of 293 COPD patients admitted to the 910th Hospital of PLA Joint Logistics Support Force from January 2021 to December 2023 were retrospectively collected.PMA and PMD were measured based on axial images above the aortic arch on chest CT.Generalized linear models were used to analyze the correlation be-tween PMA and PMD and parameters of lung function and disease severity.Results Compared with the high PMA group,the low PMA group had lower forced vital capacity(FVC),FVC as a percentage of the predicted value,forced expiratory volume in one second(FEV1),FEV1 as a percentage of the predicted value,and FEV1/FVC ratio(P<0.05),but higher CAT scores and emphysema index(P<0.05).For every 10 cm2 increase in PMA,there was a 0.17L increase in FVC,a 4.47%increase in FVC as a percentage of the predicted value,a 0.21 L increase in FEV1,an 8.02%increase in FEV1 as a percentage of the predicted value,a 0.04 increase in FEV1/FVC ratio,and a 2.58%decrease in emphysema index.Compared with the high PMD group,the low PMD group had lower FVC as a percentage of the predicted value,FEV1 as a percentage of the predicted value,and FEV1/FVC ratio(P<0.05),but a higher emphysema index(P=0.007).For every 10 HU increase in PMD,there was a 4.64%increase in FVC as a percentage of the predicted value,a 0.14 L increase in FEV1,an 8.56%increase in FEV1 as a percentage of the estimated value,and a 0.04 increase in FEV1/FVC ratio(P<0.05).Conclusions PMA and PMD measured by CT are correlated with disease severity and lung function in COPD patients,and can be used as parameters to evaluate disease severity in patients.关键词
慢性阻塞性肺疾病/胸大肌/计算机断层扫描/肺功能Key words
chronic obstructive pulmonary disease/pectoralis major muscle/CT/lung function分类
医药卫生引用本文复制引用
洪丽月,黄种杰,黄鑫成,黄文铖,郭志雄,洪原城..慢性阻塞性肺疾病患者胸大肌CT参数与肺功能及疾病严重程度的关系[J].武警医学,2024,35(7):582-587,592,7.基金项目
泉州市科技计划项目(2022N008S) （2022N008S）
