武警医学2024，Vol.35Issue(7)：607-612,6.
ctDNA在预测局部晚期直肠癌患者新辅助放化疗病理完全缓解的价值
Value of ctDNA in predicting pathological complete remission of neoadjuvant chemoradio-therapy in patients with locally advanced rectal cancer
摘要
Abstract
Objective To investigate the value of circulating tumor(ct)DNA in predicting pathological complete remission(pCR)of neoadjuvant chemoradiotherapy(nCRT)in patients with locally advanced rectal cancer(LARC).Methods A total of 104 LARC patients recruited from March 2020 to September 2021 were selected as the study objects,and the baseline data and plasma sam-ples during nCRT were collected for gene sequencing.The association between ctDNA status and treatment response was analyzed.The value of ctDNA alone,MRI alone,and the combination of ctDNA and MRI in predictive pCR was evaluated.The independent clinical factors influencing pCR were analyzed by logistic univariate and multifactorial analysis.Results Of the 104 patients,35(33.65%)a-chieved pCR after surgery,and 91(87.50%)had positive ctDNA at baseline.The proportion of negative ctDNA and ctDNA clearance before surgery in patients with pCR were significantly higher than those in patients with N-pCR(P<0.05).The proportion of ctDNA negativity and ctDNA clearance in pTRG3 patients were significantly reduced(P<0.05).Logistic univariate and multivariate analysis showed that ctDNA clearance and cCR were independent clinical factors affecting pCR(P<0.05).The area under the pCR curve of ctDNA clearance combined with MRI diagnosis was 0.937(0.885-0.989),which was higher than that of ctDNA clearance or MRI a-lone.Conclusions The standard of clinical complete response based on MRI combined with ctDNA has the value of predicting pCR in LARC patients.关键词
循环肿瘤DNA/局部晚期直肠癌/病理完全缓解/临床完全缓解/MRIKey words
circulating tumor DNA/locally advanced rectal cancer/complete pathological remission/clinical complete remis-sion/MRI分类
医药卫生引用本文复制引用
赵玉红,曹伟,张磊..ctDNA在预测局部晚期直肠癌患者新辅助放化疗病理完全缓解的价值[J].武警医学,2024,35(7):607-612,6.基金项目
保定市科学技术局科研计划项目(18ZF181) （18ZF181）
