武警医学2024，Vol.35Issue(7)：617-620,626,5.
老年人握力减弱与静脉血栓栓塞症发病风险的因果关系
Causal association between weakened grip strength and risk of venous thromboembolism in the elderly
摘要
Abstract
Objective To investigate causal association between weakened grip strength and the risk of venous thromboembo-lism(VTE)in the elderly.Methods The association between weakened grip strength and the risk of VTE was analyzed using Mende-lian randomization(MR),and the causal effect was mainly assessed with inverse variance weighting(IVW).The F-statistic was cal-culated to test the stability of instrumental variables,Cochran's Q-statistic was applied to test for heterogeneity,and sensitivity and plei-otropy were assessed using weighted median,MR-Egger regression and leave-one-out methods.Results There was no causal associa-tion between weakened grip strength and the risk of VTE in the elderly(OR:1.001,95%CI:0.997-1.005,P=0.524).In a fur-ther analysis of deep vein thrombosis(DVT)and pulmonary embolism(PE),similarly no causal association was found between weak-ened grip strength and the risk of DVT(OR:1.002,95%CI:0.999-1.006,P=0.254)and PE(OR:0.894,95%CI:0.700-1.141,P=0.368)in the elderly.Conclusions There is no causal association between weakened grip strength and the risk of VTE in the elderly.关键词
老年人/孟德尔随机化/握力/静脉血栓栓塞症Key words
the elderly/mendelian randomization/grip strength/venous thromboembolism分类
医药卫生引用本文复制引用
刘智强,谭江山,华潞..老年人握力减弱与静脉血栓栓塞症发病风险的因果关系[J].武警医学,2024,35(7):617-620,626,5.基金项目
中国医学科学院临床与转化医学研究专项(CIFMS)(2022-I2M-C&T-B-040) （CIFMS）
中国医学科学院阜外医院深圳医院国家心血管疾病临床医学研究中心深圳自主课题(NCRCSZ-2023-015) （NCRCSZ-2023-015）
