西安交通大学学报（医学版）2024，Vol.45Issue(4)：650-655,6.DOI:10.7652/jdyxb202404019
急性期精神分裂症患者血清胆汁酸谱与认知功能的相关性
Correlation between serum bile acid profile and cognitive function in patients with acute schizophrenia
摘要
Abstract
Objective To investigate the effect of peripheral blood bile acids on the cognitive function of schizophrenia patients.Methods Targeted metabolomics was adopted to analyze the total level of primary and secondary serum bile acid metabolites collected from 23 schizophrenia patients and 23 health control individuals.The MATRICS Consensus Cognitive Battery(MCCB)was adopted to evaluate the subjects'cognitive function in five dimensions.Results We found that the schizophrenia patients had impaired cognitive functions in multiple dimensions including speed of processing,working memory,reasoning and problem solving,and visual learning.Compared with the health control group,serum levels of cholic acid(CA)and chenodeoxycholic acid(CDCA)were significantly lower in patients with schizophrenia,while serum level of glycocholic acid(GCA)was significantly higher,and the ratio of deoxycholic acid(DCA)to CA was higher(3.04 vs.1.16).Speed of processing,working memory,reasoning and problem solving,and visual learning abilities were significantly negatively correlated with serum levels of multiple primary bile acids including taurocholic acid(TCA),GCA,glycochenodeoxycholic acid(GCDCA)and taurochenodeoxycholic acid(TCDCA),after adjustments of age,sex,and body mass index.Conclusion The bile acid profile of schizophrenia patients is obvious,and the decrease in neuroprotective bile acids(namely,CA and CDCA)and the up-regulation of cytotoxic bile acid(i.e.,GCA)may impair the cognitive function of schizophrenia patients.关键词
精神分裂症/胆汁酸谱/认知功能/神经保护Key words
schizophrenia/bile acid profile/cognitive function/neuroprotection分类
医药卫生引用本文复制引用
戚志扬,马青艳,贾敏,文炳龙,姜文慧,马现仓,范雅娟..急性期精神分裂症患者血清胆汁酸谱与认知功能的相关性[J].西安交通大学学报（医学版）,2024,45(4):650-655,6.基金项目
国家自然科学基金-青年项目(No.82201659) （No.82201659）
陕西省重点研发计划-一般项目(No.2023-YBSF-456)Supported by the National Natural Science Foundation of China(No.82201659)and Shaanxi Provincial Key Research and Development Program-General Project(No.2023-YBSF-456) （No.2023-YBSF-456）
