西安交通大学学报（医学版）2024，Vol.45Issue(4)：663-668,6.DOI:10.7652/jdyxb202404021
陕西地区健康人群血栓弹力图参考区间的建立
Establishment of reference intervals for thromboelastography in Shaanxi healthy population
摘要
Abstract
Objective To establish the reference interval of thromboelastography(TEG)for healthy adults in Shaanxi province so as to serve clinical precision blood transfusion.Methods According to the standard method of"Establishment of Reference Interval for Clinical Laboratory Test Items"(WS/T 402-2012),peripheral venous blood was collected from 386 selected patients in Shaanxi.The conventional coagulation and fibrinolysis indexes(PT,APTT,TT,FiB,FDP,and DD)were detected by hemagglutinometer,and the following parameters(R,K,Angle,MA,LY30,CI)were determined by thrombolysis graph.The 95％confidence interval was used to determine the reference interval of each parameter of thrombolysis diagram.Results The routine coagulation and fibrinolysis indexes of the 386 healthy volunteers were normal.Compared with the reference intervals of various TEG indicators provided by the manufacturer of TEG,7.2％(28/386)were diagnosed with coagulopathy,and the test specificity was only 44％(170/386).Furthermore,there was decreased R in 188 subjects(48.7％),increased K in 28 subjects(7.3％),and decreased Angle in 12 subjects(3.1％).The significant differences in R,MA and CI were found between males and females(P＜0.05).The significantly different R and CI were revealed in different age ranges(P＜0.05).Finally,the normal reference range of each parameter of thrombus elastigram in 386 cases was set for males(R:2.7-8.6,K:1.3-3.6,Angle:46.2-72.5,MA:49.5-69.3,LY30:0-8.0,CI:-3.2-3.6)and females(R:2.7-9.2,K:1.2-3.4,Angle:46.2-72.5,MA:49.5-69.3,LY30:0-8.0,CI:-3.2-3.6).Conclusion The reference interval of thrombolysis map of healthy people in Shaanxi is significantly different from that provided by the manufacturer.The thrombolysis map reference interval established in this study is more suitable for the clinical coagulation characteristics of the local population and can be better applied in clinical diagnosis and treatment services.关键词
陕西地区/血栓弹力图(TEG)/参考范围/健康人群Key words
Shaanxi Province/thromboelastogram(TEG)/reference range/healthy population分类
医药卫生引用本文复制引用
黄露杰,马捷,王咪,闫芳..陕西地区健康人群血栓弹力图参考区间的建立[J].西安交通大学学报（医学版）,2024,45(4):663-668,6.基金项目
西安市科技计划项目(No.21YXYJ0039) （No.21YXYJ0039）
陕西省自然科学基础研究计划项目(No.2022JM-440)Supported by Xi'an Science and Technology Planning Project(No.21YXYJ0039)and Natural Science Basic Research Plan of Shaanxi Province of China(No.2022JM-440) （No.2022JM-440）
