残余胆固醇水平与急性脑梗死相关性探讨OA

Objective To investigate the relationship between remnant cholesterol(RC)and acute ische-mic stroke.Methods A total of 208 patients with acute ischemic stroke admitted to the Department of Neu-rology,Affiliated Hospital of North China University of Science and Technology from October 2022 to Octo-ber 2023 were included as the case group.Concurrently,a total of 208 healthy individuals undergoing routine health check-ups served as the control group.RC values were calculated using the Friedewald equation for all study subjects.The impact of RC on acute ischemic stroke was analyzed using binary logistic regression,and the predictive efficacy of RC for the risk of acute ischemic stroke was evaluated by constructing ROC curves.The study also analyzed the relationship between different RC levels,inconsistencies between RC and LDL-C,and acute ischemic stroke.Results Comparative analysis of clinical data between the case and the control group revealed that,after controlling for other factors,RC(OR=5.839,95%CI 2.225-15.325)was an inde-pendent risk factor for acute ischemic stroke.ROC curve analysis showed that the area under the curve for RC predicting the risk of acute ischemic stroke was 0.692,with a specificity of 74%and sensitivity of 58.7%.A-nalysis of inconsistencies between RC and LDL-C indicated that compared to the consistent RC and LDL-C group,the inconsistent high RC level group had a 2.140-fold higher risk of acute ischemic stroke,while the in-consistent low RC level group exhibited a protective effect.Compared to the group with LDL-C≤3.4 mmol/L and RC≤0.62 mmol/L,the risk of acute ischemic stroke did not significantly increase when LDL-C was>3.4 mmol/L and RC≤0.62 mmol/L,whereas it increased by 3.210 times when LDL-C≤3.4 mmol/L and RC>0.62 mmol/L.Analysis of the relationship between different RC levels and acute ischemic stroke risk found that the risk of acute ischemic stroke in RC Q4(≥0.92 mmol/L)was 4.334 times that of RC Q1(≤0.51 mmol/L).Conclusion Remnant cholesterol is an independent risk factor for acute ischemic stroke,acting independently of LDL-C.Higher levels of remnant cholesterol are associated with an increased risk of acute is-chemic stroke.