现代医药卫生2024，Vol.40Issue(14)：2455-2459,5.DOI:10.3969/j.issn.1009-5519.2024.14.026
β-烟酰胺单核苷酸及其在维持基因组稳态中的研究进展
Research progress of β-nicotinamide mononucleotide and its role in maintaining genomic homeostasis
摘要
Abstract
β-nicotinamide mononucleotide(NMN)is the precursor of coenzyme Ⅰ nicotinamide adenine dinucleotide(NAD+),which plays a crucial role in complicated cellular processes,including DNA damage sig-naling pathways,redox reaction,and metabolic reaction.Supplementation of NMN to increase concentration of intracellular NAD+and enhance the capacity of DNA damage repair has become a spot of research worldwide.This review provided an overview of latest research advancements in NMN,focusing on its potential in dela-ying aging,treating diseases,maintaining genomic stability,and cellular homeostasis.The mechanism of NMN's enhancement of host DNA damage repair ability was analyzed,and the potential risks of supplemen-ting NMN were discussed to provide reference for subsequent NMN-related scientific research.关键词
β-烟酰胺单核苷酸/DNA损伤修复/烟酰胺腺嘌呤二核苷酸/多聚二磷酸腺苷核糖聚合酶/去乙酰化酶Key words
β-nicotinamide mononucleotide/Repair of DNA damage/nicotinamide adenine dinucle-otide/Poly ADP-Ribose Polymerase/Sirtuin分类
生物科学引用本文复制引用
魏明臣,牛梦伟,宋英杰,韩尧,李浩,孙岩松..β-烟酰胺单核苷酸及其在维持基因组稳态中的研究进展[J].现代医药卫生,2024,40(14):2455-2459,5.基金项目
国家自然科学基金项目(31901051) （31901051）
国家科技重大专项课题(2018ZX10301-407). （2018ZX10301-407）
