新发传染病电子杂志2024，Vol.9Issue(3)：40-44,5.DOI:10.19871/j.cnki.xfcrbzz.2024.03.009
血清转化生长因子-β、白细胞介素-23在婴幼儿呼吸道合胞病毒肺炎患儿中的表达及其与病情严重程度的相关性
The expression of serum TGF-β and IL-23 in infants with respiratory syncytial virus pneumonia and their correlation with the severity of the disease
摘要
Abstract
Objective To observe the expression of serum transforming growth factor-β(Transforming growth factor-β,TGF-β)and interleukin 23(Interleukin 23,IL-23)in infants with respiratory syncytial virus(RSV)pneumonia,and to analyze the possible relationship between TGF-β,IL-23 and the severity of the disease.Method The data of 100 infants with RSV pneumonia admitted to Chenzhou First People's Hospital from January 2021 to December 2023 were collected and included in the observation group.The data of 100 infants who underwent physical examination in the hospital during the same period were collected and included in the control group.The disease data and physical examination data of children and healthy infants were preserved intact.The observation group were divided into mild group(n=37)and severe group(n=63)according to the severity of the disease after admission.The levels of TGF-β and IL-23 in the control group and children with different severity of disease,the baseline data of children with different severity of disease,and the levels of TGF-β and IL-23 were compared.The correlation between serum TGF-β and IL-23 and the severity of respiratory syncytial virus pneumonia in infants was analyzed.Result Compared with the control group,the mild group and the severe group had lower TGF-β and higher IL-23;compared with the mild group,the TGF-β in the severe group was lower and the IL-23 was higher(P＜0.05).Through Logistic regression analysis,the severity of RSV pneumonia in infants and young children may be related to TGF-β,and IL-23 levels(P＜0.05).The ROC curve results showed that TGF-βand IL-23 at the time of admission had a certain efficacy in assessing severe illness,with AUC greater than 0.70 and evaluation value.Moreover,the combined evaluation AUC of the two was 0.937,indicating better evaluation value(P＜0.05).Conclusion The serum levels of TGF-β and IL-23 in infants with RSV pneumonia are generally low and high,and the two are related to the severity of the disease.The more severe the disease,the lower the TGF-β and the higher the IL-23.The combined determination of TGF-β and IL-23 levels in infants with RSV pneumonia may be used to evaluate the severity of the disease in early stage.关键词
肺炎/呼吸道合胞病毒/转化生长因子-β/白细胞介素-23/病情严重程度/相关性Key words
Pneumonia/Respiratory syncytial virus/Transforming growth factor-β/Interleukin-23/Severity of the disease/Correlation分类
医药卫生引用本文复制引用
唐绘卓,伍洪华,李小梅..血清转化生长因子-β、白细胞介素-23在婴幼儿呼吸道合胞病毒肺炎患儿中的表达及其与病情严重程度的相关性[J].新发传染病电子杂志,2024,9(3):40-44,5.基金项目
1.郴州市科技计划项目(zdyf201959) （zdyf201959）
2.湘南学院科学研究项目(2021XJ133) （2021XJ133）
