摘要
Abstract
Objective To explore the value of dual energy CT(DECT)enhanced scanning and magnetic resonance elastography(MRE)in the diagnosis of hepatitis B liver fibrosis,and provide reference for clinical application.Method From July 2022 to July 2023,a retrospective study was carried out on the clinical diagnosis and treatment data of 85 patients with chronic hepatitis B diagnosed and treated in Department of Radiography of Luohu Hospital of Traditional Chinese Medicine,Guangdong Shenzhen.All patients in this group underwent DECT scans and MRE examinations.Based on the pathological biopsy results as the gold standard,they were divided into S0 group,S1-S2 group,and S3-S4 group according to the severity of liver fibrosis.The MRE elasticity values,arterial hepatic parenchymal iodine concentration(Ia),portal venous hepatic parenchymal iodine concentration(Ip),and hepatic arterial iodine fraction(AIF)were compared among the three groups;Analyze the correlation between liver fibrosis grading and the above indicators through Spearman correlation coefficient,and analyze the efficacy of clinical diagnosis.Result Pathological biopsies of 105 patients in this group showed that there were 28 cases in group S0,35 cases in group S1-S2,and 22 cases in group S3-S4.There was no significant difference in the basic clinical data of the three groups(P＞0.05).The MRE elastic value,Ia,Ip and AIF of S0 group,Sl-S2 group and S3-S4 group were significantly different(P＜0.05).Spearman correlation analysis showed that the severity of hepatitis B fibrosis was positively correlated with MRE elasticity score,Ia and AIF(r=0.705,0.543,0.685,P＜0.05),and negatively correlated with Ip(r=-0.607,P＜0.05).The sensitivity,specificity and accuracy of MRE and DECT enhanced scanning in the diagnosis of hepatitis B fibrosis were significant(P＜0.05).According to ROC curve analysis,the AUC of DECT enhanced scan,MRE and combined diagnosis of HBV fibrosis were 0.769、0.833、0.926,respectively.Conclusion In the diagnosis of hepatitis B liver fibrosis,DECT enhanced scanning and MRE examination have good results,and the combined diagnosis of both can improve the diagnostic efficiency and has important clinical value.关键词
双能量CT增强/磁共振弹性成像/慢性乙型肝炎肝纤维化/诊断效能Key words
Dual-energy CT enhancement/Magnetic resonance elastography/Hepatitis B liver fibrosis/Diagnostic efficiency分类
医药卫生
