协和医学杂志2024，Vol.15Issue(4)：825-830,6.DOI:10.12290/xhyxzz.2024-0204
859例胰腺占位性病变超声造影诊断的准确性分析
Accuracy of Contrast-Enhanced Ultrasound Diagnostic Reports for 859 Cases of Pancreatic Space-occupying Lesions
摘要
Abstract
Objective To evaluate the accuracy of contrast-enhanced ultrasound diagnostic reports for pancreatic lesions.Methods In this retrospective study,we included patients who underwent contrast-enhanced ultrasound examination of pancreatic lesions at Peking Union Medical College Hospital from January 2017 to December 2022 and received a confirmed pathological diagnosis.Using pathological diagnosis as the gold standard,the study evaluated the accuracy of contrast-enhanced diagnostic ultrasound.It also analyzed the misdiagnosis of contrast-enhanced ultrasound in diagnosing various pathological types of pancreatic lesions.Results Of the 859 patients who met inclusion and exclusion criteria,489 were male(56.9%)and 370 were female(43.1%).Their age ranged from 16 to 85 years,with a median age of 60(53,66)years.Except for 47 pancreatic space-occupying lesions that were difficult to categorize as either benign or malignant,a total of 812 cases were included in the diagnostic efficacy analysis of benign and malignant lesions.The results sugges-ted that the diagnostic sensitivity and specificity of contrast-enhanced ultrasound for pancreatic malignant lesions were 98.3%(95%CI:97.1%-99.1%)and 79.0%(95%CI:70.1%-86.4%),AUC was 0.887(95%CI:0.863-0.908),positive and negative predictive value were 96.9%(95%CI:95.6%-97.9%)and 87.4%(95%CI:79.6%-92.4%),positive and negative likelihood ratio were 4.69(95%CI:3.24-6.80)and 0.02(95%CI:0.01-0.04).The diagnostic accuracy rate of contrast-enhanced ultrasound for di-agnosing benign and malignant pancreatic lesions was 95.8%.Of the 859 lesions examined,48 cases were mis-diagnosed by contrast-enhanced ultrasound,with a misdiagnosis rate of 5.6%(48/859),including 7 cases(0.8%)of undetermined diagnosis,while the diagnostic accuracy of pancreatic ductal adenocarcinoma was as high as 98.8%.No complications occurred in any of the patients.Conclusions Contrast-enhanced ultrasound is a safe and effective imaging method for evaluating microvascular perfusion in various pancreatic lesions.It has significant clinical value in diagnosing both benign and malignant pancreatic lesions,particularly in diagnosing pancreatic ductal adenocarcinoma.关键词
超声造影/胰腺导管腺癌/胰腺神经内分泌肿瘤/胰腺肿瘤/自身免疫性胰腺炎Key words
contrast-enhanced ultrasound/pancreatic ductal adenocarcinoma/pancreatic neuroendocrine neoplasms/pan-creatic tumor/autoimmune pancreatitis分类
医药卫生引用本文复制引用
桂阳,吕珂,梁华,陈雪琪,贾琬莹,陈天娇,姜玉新..859例胰腺占位性病变超声造影诊断的准确性分析[J].协和医学杂志,2024,15(4):825-830,6.基金项目
中央高水平医院临床科研专项(2022-PUMCH-D-001,2022-PUMCH-B-065) （2022-PUMCH-D-001,2022-PUMCH-B-065）
国家自然科学基金(82171968) National High Level Hospital Clinical Research Funding(2022-PUMCH-D-001,2022-PUMCH-B-065) （82171968）
National Natural Science Foundation of China(82171968) （82171968）
