协和医学杂志2024，Vol.15Issue(4)：839-844,6.DOI:10.12290/xhyxzz.2023-0544
卵巢癌患者肿瘤细胞减灭术前低蛋白血症与围术期异体红细胞输注风险的相关性:单中心回顾性队列研究
Association Between Preoperative Hypoalbuminemia and Risk of Perioperative Allogeneic Red Blood Cell in Patients Undergoing Cytoreductive Surgery for Ovarian Cancer:A Single-center Retrospective Cohort Study
摘要
Abstract
Objective To analyze the correlation between preoperative hypoproteinemia and the risk of perioperative allogeneic erythrocyte transfusion in ovarian cancer patients undergoing cytoreductive surgery.Methods Ovarian cancer patients who underwent cytoreductive surgery at Peking Union Medical College Hos-pital from January 2014 to December 2018 were retrospectively included.Clinical data such as the patients'general information,preoperative plasma albumin,American Society of Anesthesiologists(ASA)classification,intraoperative bleeding volume,operation time,perioperative(intraoperative and within 3 d postoperatively)allogeneic red blood cell transfusion were collected,and the correlation between preoperative hypoproteinemia(plasma albumin＜35 g/L)and the risk of allogeneic red blood cell infusion was analyzed by using multivariate Logistic regression.Results A total of 1001 ovarian cancer patients who met the inclusion and exclusion crite-ria were enrolled,of which 64(6.4%)had preoperative hypoproteinemia and 481(48.1%)received periop-erative allogeneic red blood cell transfusion.The rate of perioperative allogeneic red blood cell transfusion was higher in the patients with hypoproteinemia than in those without hypoproteinemia[84.4%(54/64)vs.45.6%(427/937),P＜0.001].Multivariate Logistic regression analysis corrected for confounders such as ASA classification,intraoperative bleeding volume,and operative time found that preoperative hypoproteinemia was significantly associated with the risk of perioperative allogeneic red blood cell transfusion(OR=5.68,95%CI:2.56-13.57,P＜0.001).Conclusion Preoperative hypoalbuminemia could be associated with the in-creased risk of perioperative transfusion in patients undergoing cytoreductive surgery for ovarian cancer.关键词
低蛋白血症/卵巢癌/肿瘤细胞减灭术/异体红细胞输注Key words
hypoproteinemia/ovarian cancer/tumor cell reduction/allogeneic red blood cell infusion分类
医药卫生引用本文复制引用
刘薇,徐宵寒,虞雪融..卵巢癌患者肿瘤细胞减灭术前低蛋白血症与围术期异体红细胞输注风险的相关性:单中心回顾性队列研究[J].协和医学杂志,2024,15(4):839-844,6.基金项目
国家自然科学基金(72304281) （72304281）
中央高水平医院临床科研专项(2022-PUMCH-B-119) National Natural Science Foundation of China(72304281) （2022-PUMCH-B-119）
National High Level Hospital Clinical Research Fun-ding(2022-PUMCH-B-119) （2022-PUMCH-B-119）
