协和医学杂志2024，Vol.15Issue(4)：891-896,6.DOI:10.12290/xhyxzz.2023-0656
反义寡核苷酸的作用机制及其在运动系统中的研究进展
Mechanism of Action of Antisense Oligonucleotides and Their Research Progress in the Musculoskeletal System
摘要
Abstract
Antisense oligonucleotides(ASOs)are a novel class of small molecule gene-targeted drugs that can bind with target mRNA.Through complementary base pairing with the target sequence,antisense oligo-nucleotides achieve targeted regulation of genes.With the continuous development of gene sequencing technology and molecular synthesis techniques,research and applications of ASOs in the musculoskeletal system have further advanced.This article reviews the mechanisms of ASOs in gene silencing and expression regulation,as well as their prospects in gene therapy.It also evaluates the research progress and applications of ASOs in musculoskeletal diseases and analyzes the urgent issues currently faced by this class of drugs.This comprehensive study aims to deepen our understanding of ASOs and provide valuable reference for their wide-spread application in biomedical research and clinical settings.关键词
反义寡核苷酸/基因治疗/临床应用/运动系统Key words
antisense oligonucleotides/gene therapy/clinical practice/musculoskeletal system分类
医药卫生引用本文复制引用
杨建乐,吴南..反义寡核苷酸的作用机制及其在运动系统中的研究进展[J].协和医学杂志,2024,15(4):891-896,6.基金项目
中国医学科学院医学与健康科技创新工程(2021-I2M-1-051) （2021-I2M-1-051）
中央高水平医院临床科研专项(2022-PUMCH-C-033) CAMS Innovation Fund for Medical Sciences(2021-I2M-1-051) （2022-PUMCH-C-033）
National High Level Hospital Clinical Research Funding(2022-PUMCH-C-033) （2022-PUMCH-C-033）
