协和医学杂志2024，Vol.15Issue(4)：953-959,7.DOI:10.12290/xhyxzz.2023-0595
西藏地区膀胱尿路上皮癌患者GATA-3和H3K27me3的表达及其临床意义
Expression and Significance of GATA-3,H3K27me3 in Tibetan Patients with Bladder Urothelial Carcinoma
摘要
Abstract
Objective To investigate the expression and clinical significance of GATA-3 and H3K27me3 in Tibetan patients with bladder urothelial carcinoma(BUC).Methods BUC and normal bladder tissues were collected retrospectively from January 2016 to December 2021 in the People's Hospital of Tibet Autonomous Region.The expression of GATA-3 and H3K27me3 in both tissues was detected by immunohisto-chemical method,and the clinical and pathological characteristics were statistically analyzed.Results A total of 70 patients with BUC were selected,including 51 males and 19 females,with an average age of(60.5±12.0)years.At the same time,20 normal bladder tissue samples were collected during the same period.All cases were Tibetan patients.Immunohistochemistry results showed that the high expression rate of GATA-3 in BUC and normal bladder tissue was 70.0%(49/70)and 100%(20/20),respectively.High expression of GATA-3 was associated with male,low pathological grade,and non-invasive tissue(all P＜0.05).The high expression rate of H3K27me3 in BUC and normal bladder tissue was 45.7%(32/70)and 20.0%(4/20),respectively.High expression of H3K27me3 was only associated with male(P=0.011).Conclusions The ex-pression of GATA-3 was down regulated in Tibetan BUC patients,and significantly down regulated with the in-crease of tumor grade,suggesting that GATA-3 may be involved in the occurrence and development of BUC and related to its malignancy,providing reference for clinical diagnosis and treatment as well as judging disease prognosis.The expression of H3K27me3 in Tibetan BUC patients was higher than that in normal bladder tissue,suggesting that H3K27me3 may be a new immune marker for diagnosis of BUC.关键词
西藏地区/膀胱尿路上皮癌/临床病理特征/GATA-3/H3K27me3Key words
Tibet/bladder urothelial carcinoma/clinicopathological characteristics/GATA-3/H3K27me3分类
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尼玛卓玛,肖雨,罗含欢,多布啦,王寒,达珍,斯朗江村,郭平平,廖瑞倩..西藏地区膀胱尿路上皮癌患者GATA-3和H3K27me3的表达及其临床意义[J].协和医学杂志,2024,15(4):953-959,7.基金项目
西藏自治区自然科学基金组团式援藏医学项目(XZ2020ZR-ZY23[Z]) Tibet Natural Science Foundation of China(XZ2020ZR-ZY23[Z]) （XZ2020ZR-ZY23[Z]）
