我国猪链球菌对常用抗菌药物耐药性的Meta分析OA北大核心CSTPCD

To systematically analyze the antimicrobial resistance of Streptococcus suis(S.suis)to commonly used antimicrobials in China over the past decade,and analyze their temporal changes and geographic characteristics,so as to provide scientific guidance for monitoring the resistance trends of S.suis,rational use of antimicrobials,and development of new drugs.In this project,the existing literature was collected and organized,and Meta-analysis was performed.Inclusion and exclusion criteria were set up,relevant literature was screened,and a database on the resistance status of S.suis to commonly used antimicrobial drugs in China was established,and the literature in the database was subjected to the steps of quality evaluation,heterogeneity test,publication bias test,and subgroup analysis as well as statistical calculations.The results showed that different resistance status of S.suis to 20 commonly used antimicrobial drugs,with the highest resistant rates to tetracyclines and lincosamides(＞80％,91％for tetracycline,84％for lincomycin,81％for doxycycline and 81％for clindamycin),followed by aminoglycosides(50％to 80％,76％for erythromycin,76％for kanamycin 75％,azithromycin 74％,streptomycin 70％,cotrimoxazole 65％,gentamicin 64％,amikacin 55％);penicillins,cephalosporins,phenicols,fluoroquinolones(10％to 40％;enrofloxacin 37％,florfenicol 31％,ciprofloxacin 30％,penicillin 24％,chloramphenicol 24％,ampicillin 13％,ceftiofur 12％),and vancomycin,with the lowest resistant rate of 4％.Subgroup analysis showed that the resistant rate varied depending on their isolation year and area.Increasing resistance of S.suis to commonly used antimicrobials were observed during the past decade.Strategies are urgently needed to tackle antimicrobial resistance of S.suis in China in premise of strengthen surveillance,reduce the irrational use and explore the resistance mechanism.