植物乳杆菌胞外多糖对断奶仔猪生长性能、血清生化与免疫指标及肠道组织学的影响OA北大核心CSTPCD

This study was to explore the effects of exopolysaccharides of Lactobacillus plantarum(LP-EPS)on the growth,serum immuni-ty,antioxidant indexes,intestinal morphological structure and intestinal cell apoptosis in weaned piglets.100 weaned pigs of(Duroc×Land-race×Large class)with similar body weight were selected and randomly divided into the experimental group and the control group,with 50 piglets in each group.The experimental group was fed with basal diet+LP-EPS 0.4 mg/kg,and the control group was fed with basal diet.The trial period was 30 d.During the test,the performance indexes of the two groups of weaned pigs were measured and counted;and at the end of the test,blood and intestinal tissue samples were collected from the piglets,and intestinal cell apoptosis was detected by biochemical and immune tests,HE staining of intestinal tissue and Tunel assay.The results showed that the LP-ESP additive decreased the rate of diar-rhea and mortality of the piglets,increased their average daily weight gain(P＜0.05),decreased their meat to feed ratio(P＜0.05),and in-creased the level of total protein,albumin,immunoglobulin G,immunoglobulin A and total antioxidant capacity in serum(P＜0.05).Fur-thermore,the addition of LP-EPS significantly increased the villi height of the duodenum,jejunum,and cecum(P＜0.05),as well as the caecal villi height/crypt depth in the duodenum and cecum(P＜0.05).Daily dietary addition of LP-EPS significantly reduced apoptosis in the jejunum(P＜0.001)and cecum(P＜0.01)in the piglets.In conclusion,0.4 mg/kg LP-EPS added to the diet promoted the growth per-formance of the weaned piglets,improved their intestinal villus morphology,enhanced their immune function and antioxidant function,and reduced intestinal cell apoptosis in them.