信阳师范学院学报（自然科学版）2024，Vol.37Issue(3)：412-420,9.DOI:10.3969/j.issn.1003-0972.2024.03.019
2023年诺贝尔生理学与医学奖解读
Introduction of the 2023 Nobel Prize in Physiology or Medicine:Nucleoside Base Modification and mRNA Vaccine
摘要
Abstract
The 2023 Nobel Prize in Physiology or Medicine was awarded to Katalin KARIKÓ and Drew WEISSMAN for their discovery of nucleoside base modification.The study of two scientists found that in vitro transcribed mRNA with modified bases can escape adverse immune reaction and also found that mRNA containing pseudouridine can be translated more effectively.Based on the research of two scientists,the delivery systems have been developed efficiently.The nucleoside modification,mRNA vaccine,lipid nanoparticles,mRNA vaccine application prospect were introduced.关键词
诺贝尔生理学或医学奖/mRNA疫苗/核苷修饰/脂质纳米颗粒/新型冠状病毒疫苗Key words
Nobel Prize in Physiology or Medicine/mRNA vaccine/nucleoside modification/lipid nanoparticles/SARS-CoV-2 vaccine分类
生物科学引用本文复制引用
宋新强,易朝辉,张牧,张婉莹,王雨洋..2023年诺贝尔生理学与医学奖解读[J].信阳师范学院学报（自然科学版）,2024,37(3):412-420,9.基金项目
国家自然科学基金项目(U1804179) （U1804179）
河南省科技攻关项目(202102310190) （202102310190）
河南省创新型科技团队项目(2017083) （2017083）
