新医学2024，Vol.55Issue(6)：437-442,6.DOI:10.3969/j.issn.0253-9802.2024.06.006
宫内高血糖对新生儿炎症因子水平及婴儿过敏性疾病发生的影响
Effect of intrauterine hyperglycemia on levels of neonatal inflammatory cytokines and the occurrence of allergic diseases in infants
摘要
Abstract
Objective To evaluate the effect of intrauterine hyperglycemia exposure on inflammatory cytokine levels in neonatal umbilical cord blood and the incidence of allergic diseases in infants.Methods 112 pregnant women and their infants were enrolled.According to the glucose levels during pregnancy,all women were divided into the intrauterine hyperglycemia exposure(n=55)and non-intrauterine hyperglycemia exposure groups(n=57).The levels of inflammatory cytokines in the umbilical cord blood were compared between two groups.During 1-year follow-up,the incidence of allergic diseases such as atopic dermatitis and wheezing in infants was compared between two groups.The impact of intrauterine hyperglycemia on neonatal immunity and infant allergic diseases was evaluated.Results There were no significant differences in the levels of IL-1β,IL-2,IL-6,IL-8,IL-10,IL-12 and TNF-α between two groups(all P＞0.05).In the intrauterine hyperglycemia exposure group,the IL-4 level in the umbilical cord blood was(30.180±8.648)pg/mL,significantly higher than(22.500±10.100)in the non-intrauterine hyperglycemia exposure group(P＜0.05).In the intrauterine hyperglycemia exposure group,the incidence of allergic diseases was 34.7%,higher compared with 24.0%in the non-intrauterine hyperglycemia exposure group during 1-year follow-up.However,there was no significant difference between two groups(P＞0.05).Conclusion Intrauterine hyperglycemia exposure exerts certain effect on the IL-4 level in the neonatal cord blood,which may provide evidence for early intervention of allergic diseases.关键词
新生儿/脐带血/细胞因子/宫内高血糖/过敏Key words
Newborn/Umbilical cord blood/Cytokine/Intrauterine hyperglycemia/Allergy引用本文复制引用
陈晓玲,黄向贵,周泳宜,罗立荣,黄为民..宫内高血糖对新生儿炎症因子水平及婴儿过敏性疾病发生的影响[J].新医学,2024,55(6):437-442,6.基金项目
广东省医学科学技术研究基金项目(2021112219506297) （2021112219506297）
