眼科学报2024，Vol.39Issue(3)：120-128,9.DOI:10.12419/24031601
骨关节炎和青光眼的双向孟德尔随机化研究
A bidirectional Mendelian randomization study on the association between osteoarthritis and glaucoma
摘要
Abstract
Objective:To investigate the potential bidirectional causal association between osteoarthritis and glaucoma through the application of bidirectional Mendelian randomization(MR).Methods:Instrumental variables were selected in this study based on single nucleotide polymorphisms(SNP)strongly associated with osteoarthritis and glaucoma,as utilizing genome-wide association studies(GWAS)data.The inverse variance weighting(IVW)method was served as the primary analytical approach,while the weighted median mode,simple plurality and MR-Egger regression methods were employed as complementary methods.Sensitivity analyses were conducted using F-statistic,Cochran Q-test,MR Egger's intercept test,leave-one-out,and multiplicity of residuals and outliers method(MR-PRESSO).The ratio of odds ratios(OR)was adopted as the primary effect estimate,and the strength of association was evaluated by 95%confidence interval(CI)to explore the bidirectional causal relationship between osteoarthritis and glaucoma.Results:The IVW analysis revealed that osteoarthritis elevates the risk of glaucoma with an odds ratio of(OR)of 1.10(95%CI:1.00-1.20).While the adjunctive methods concurred with this causal direction,their findings did not reach statistical significance.In contrast,the inverse Mendelian randomization(MR)analysis utilizing the inverse variance weighting method demonstrated that glaucoma does not enhance the risk of developing osteoarthritis(OR=1.02,95%CI:0.97-1.08).This conclusion was upheld by all four auxiliary methods.The F-statistic values for the selected SNP exceeded 10,indicating the absence of weak instrumental variables.Furthermore,the Cochran Q test,MR-Egger intercept test,and MR-PRESSO analyses revealed no evidence of heterogeneity or horizontal pleiotropy among the SNP.However,the inverse MR analysis displayed heterogeneity in the Cochran Q test,yet no horizontal pleiotropy was detected.The leave-one-out method analysis identified no significant influence of any individual SNP on the overall results.Conclusions:Forward MR analyses indicated that osteoarthritis may serve as a risk factor for glaucoma,indicating a positive correlation between the two conditions.Conversely,reverse MR analysis failed to establish a causal link between glaucoma and osteoarthritis.关键词
骨关节炎/青光眼/孟德尔随机化/因果关系Key words
osteoarthritis/glaucoma/mendelian randomization/causal relationship分类
医药卫生引用本文复制引用
许凯,梁江..骨关节炎和青光眼的双向孟德尔随机化研究[J].眼科学报,2024,39(3):120-128,9.基金项目
贵州省"十四五"中医药、民族医药重点学科建设.This work was supported by the Key discipline construction of traditional Chinese medicine and ethnic medicine in Guizhou Province during the"14th Five-Year Plan"period. （）
