眼科学报2024，Vol.39Issue(3)：145-152,8.DOI:10.12419/24040401
圆锥角膜铁稳态失衡的研究进展
Recent advances in research on iron homeostasis imbalance in Keratoconus
摘要
Abstract
Iron ions are essential for normal metabolism,DNA synthesis,and cellular repair in corneal cells.Nevertheless,an excess of these ions can disrupt iron homeostasis,leading to cellular toxicity,damage,and death.Keratoconus,the most prevalent ectatic corneal disorder,is often marked by the Fleischer ring,which indicates an imbalance in iron homeostasis.A review of early studies on keratoconus and iron metabolism suggests that this imbalance may be a potential pathogenic mechanism contributing to the onset and progression of the disease.This article aims to provide a comprehensive overview of normal iron metabolism in the human body and cornea,highlighting the evidence of iron homeostasis imbalance in keratoconus.It also explores potential therapeutic strategies focused on maintaining iron homeostasis,thereby offering novel insights into the treatment of ectatic eye diseases.关键词
圆锥角膜/扩张性眼病/铁稳态失衡/氧化应激/铁代谢Key words
keratoconus/ectatic eye disease/iron homeostasis imbalance/oxidative stress/iron metabolism分类
医药卫生引用本文复制引用
韩佳栩,伍涵有,顾峰,玄猛,薛建文,梁凌毅,程伟靖..圆锥角膜铁稳态失衡的研究进展[J].眼科学报,2024,39(3):145-152,8.基金项目
国家自然科学基金面上项目(82371021) （82371021）
国家自然科学基金青年项目(82301253) （82301253）
广东省基础与应用基础研究基金省市联合基金青年基金(2022A151511).This work was supported by the General Program of National Natural Science Foundation of China(82371021) （2022A151511）
Youth Project of National Natural Science Foundation of China Youth Project(82301253) （82301253）
Youth Project of Guangdong Basic and Applied Basic Research Foundation,China(2022A151511). （2022A151511）
