疑难病杂志2024，Vol.23Issue(7)：775-778,783,5.DOI:10.3969/j.issn.1671-6450.2024.07.002
兰索拉唑与雷贝拉唑治疗食管癌术后反流性食管炎的疗效比较
Comparison of lansoprazole and rabeprazole in the treatment of reflux esophagitis after operation of esophageal carci-noma
摘要
Abstract
Objective To compare the therapeutic effects of lansoprazole and rabeprazole on postoperative reflux esophagitis in patients with esophageal cancer.Methods Two hundred and two patients with postoperative reflux esoph-agitis diagnosed in our hospital from August 2019 to October 2023 were randomly divided into experimental group(n=101)and control group(n=101).The control group was given routine support therapy and rabeprazole sodium enteric-coated capsule oral treatment,while the experimental group was given routine support therapy and lansoprazole capsule oral treat-ment.The therapeutic effects and adverse drug reactions were compared between the two groups after 4 weeks of treatment,and the levels of digestive function related indexes(Gas,MTL,CGRP)and serum inflammation related indexes(IL-4,IL-6,IL-17,IL-23)were compared between the two groups.Results There was no significant difference in the total effective rate between the test group and the control group(P＞0.05).After 4 weeks of treatment,the levels of Gas and MTL in the test group were higher than patients in the control group,while CGRP was signicantly lower than patients in the control group(t/P=9.550/＜0.001,7.735/＜0.001,12.398/＜0.001).The serum levels of IL-6,IL-17 and IL-23 in the test group were signifi-cantly lower than patients in the control group,while IL-4 was higher(t/P=13.039/＜0.001,22.533/＜0.001,7.635/＜0.001,7.682/＜0.001).There was no significant difference in the incidence of total adverse reactions between the two groups(P＞0.05).Conclusion Both lansoprazole and rabeprazole can significantly relieve the symptoms of postoperative reflux esoph-agitis in patients with esophageal cancer,in which lansoprazole can better improve the digestive function,reduce the level of inflammation,which has a broader prospect of clinical application.关键词
食管癌术后反流性食管炎/兰索拉唑/雷贝拉唑/疗效Key words
Postoperative reflux esophagitis of esophageal cancer/Lansoprazole/Rabeprazole/Therapeutic effect分类
临床医学引用本文复制引用
刘文,罗继文,杨艳刚,任杰..兰索拉唑与雷贝拉唑治疗食管癌术后反流性食管炎的疗效比较[J].疑难病杂志,2024,23(7):775-778,783,5.基金项目
四川省卫生健康委科研课题(19PJ047) Research Project of Sichuan Provincial Health Commission(19PJ047) （19PJ047）
